EC Number   |
Subunits |
Reference |
|---|
   3.4.22.46 | ? |
x * 113600, P1a-HCPro unprocessed product, SDS-PAGE |
732976 |
| 3.4.22.46 | ? |
x * 72900, enzyme with the C-terminus cleaved off, SDS-PAGE |
731065 |
| 3.4.22.46 | ? |
x * 77500, enzyme with the C-terminus intact, SDS-PAGE |
731065 |
| 3.4.22.46 | dimer |
dimer in solution, determined by NMR-spectroscopy. Dimer can not be dissociated by increasing the ionic strength or by dilution |
681455 |
| 3.4.22.46 | homodimer |
2 * 19100, calculated from amino acid sequence |
732973 |
| 3.4.22.46 | homodimer |
2 * 28800, SDS-PAGE |
732973 |
| 3.4.22.46 | More |
the peptide binding cleft, which contains the active site at its centre, is located at the interface between two beta-barrels. Unusually, picornaviral 3Cpro possess a Cys-His-Asp/Glu catalytic triad at the centre of this cleft, instead of the Ser-His-Asp arrangement of active-site residues |
709535 |
