1.14.18.4 | More |
topology predictions for the castor DELTA12-hydroxylase. The RcFAH12 sequence is divided into nine consecutive domains from I through to IX: domain I is the cytosolic N-terminal region, domain II is two transmembrane helices (TM1 and TM2) connected by a short ER luminal loop, domain III is a short cytosolic loop containing the first histidine box that is involved in the catalytic site, domain IV is the first peripheral membrane-associated segment (PMS1), domain V is the second short cytosolic loop containing the second histidine box, domain VI is the second peripheral membrane-associated region (PMS2), domain VII is the third short cytosolic loop, domain VIII is the second group of transmembrane helices (TM3 and TM4) that are connected by a short ER luminal loop, and domain IX is the cytosolic C terminus containing the third histidine motif |
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