EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
6.3.1.9 | 2 glutathione + spermidine + 2 ATP |
important reaction in defense against chemical and oxidant stress, thiol redox homeostasis, ribonucleotide metabolism, and drug resistance in parasitic kinetoplastids |
Trypanosoma brucei |
N1,N8-bis(glutathionyl)spermidine + 2 ADP + 2 phosphate |
- |
? |
6.3.1.9 | 2 glutathione + spermidine + 2 ATP |
trypanothione synthase overall reaction |
Trypanosoma brucei |
N1,N8-bis(glutathionyl)spermidine + 2 ADP + 2 phosphate |
- |
? |
6.3.1.9 | 2 glutathione + spermidine + 2 ATP |
trypanothione synthase overall reaction |
Crithidia fasciculata |
N1,N8-bis(glutathionyl)spermidine + 2 ADP + 2 phosphate |
- |
? |
6.3.1.9 | 2 glutathione + spermidine + 2 ATP |
trypanothione synthase overall reaction |
Leishmania major |
N1,N8-bis(glutathionyl)spermidine + 2 ADP + 2 phosphate |
- |
? |
6.3.1.9 | 2 glutathione + spermidine + 2 ATP |
trypanothione synthase overall reaction, trypanothione metabolism overview |
Trypanosoma brucei |
N1,N8-bis(glutathionyl)spermidine + 2 ADP + 2 phosphate |
- |
? |
6.3.1.9 | 2 glutathione + spermidine + 2 ATP |
overall reaction, the enzyme catalyzes the formation of N1,N8-bis(glutathionyl)spermidine in two reaction steps, exhibiting activity of EC 6.3.1.8, glutathionylspermidine synthase, and 6.3.1.9, trypanothione synthase |
Trypanosoma brucei |
N1,N8-bis(glutathionyl)spermidine + 2 ADP + 2 phosphate |
- |
? |
6.3.1.9 | 2 glutathione + spermidine + 2 ATP |
overall reaction, the enzyme catalyzes the formation of N1,N8-bis(glutathionyl)spermidine in two reaction steps, exhibiting activity of EC 6.3.1.8, glutathionylspermidine synthase, and 6.3.1.9, trypanothione synthase, overview |
Leishmania major |
N1,N8-bis(glutathionyl)spermidine + 2 ADP + 2 phosphate |
- |
? |
6.3.1.9 | 2 glutathione + spermidine + 2 ATP |
overall reaction, the enzyme catalyzes the formation of N1,N8-bis(glutathionyl)spermidine in two reaction steps, exhibiting activity of EC 6.3.1.8, glutathionylspermidine synthase, and 6.3.1.9, trypanothione synthase |
Trypanosoma brucei 449 |
N1,N8-bis(glutathionyl)spermidine + 2 ADP + 2 phosphate |
- |
? |
6.3.1.9 | gamma-L-Glu-L-alpha-aminobutyrylglycine + N1-(gamma-Glu-L-Cys-Gly)-spermidine + ATP |
gamma-L-Glu-L-alpha-aminobutyrylglycine i.e. ophthalmic acid |
Crithidia fasciculata |
? |
- |
? |
6.3.1.9 | gamma-L-Glu-L-Cys-Gly + N1-(gamma-Glu-L-Cys-Gly)-spermidine + ATP |
synthesis of trypanothione, which is involved in maintaining intracellular thiol redox and in defense against oxidants |
Crithidia fasciculata |
N1,N8-bis-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate |
- |
? |