EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
    5.3.99.4 | (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate |
i.e. prostaglandin H2 |
Homo sapiens |
(5Z,13E)-(15S)-6,9alpha-epoxy-11a,15-dihydroxyprosta-5,13-dienoate |
prostaglandin I2 |
? |
| 5.3.99.4 | (5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate |
- |
Homo sapiens |
(5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate |
- |
? |
| 5.3.99.4 | 10-hydroperoxyoctadeca-8,12-dienoic acid |
- |
Homo sapiens |
10-oxooctadeca-8,12-dienoic acid + 10-oxodec-8-enoic acid + 10-hydroxyoctadeca-8,12-dienoic acid |
- |
? |
| 5.3.99.4 | 15-hydroperoxyeicosatetraenoic acid |
- |
Homo sapiens |
13-hydroxy-14,15-epoxy-5,8,11-eicosatrienoic acid + 15-ketoeicosatetraenoic acid + 13-hydroxy-14,15-epoxy-5,8,11-eicosatrienoic acid + 15-ketoeicosatetraenoic acid |
13-hydroxy-14,15-epoxy-5,8,11-eicosatrienoic acid and 15-ketoeicosatetraenoic acid result from homolytic cleavage of the O-O bond, whereas 13-hydroxy-14,15-epoxy-5,8,11-eicosatrienoic acid + 15-ketoeicosatetraenoic acid results from heterolytic cleavage. About 80% of substrate is cleaved homolytically, and maximal velocity of homolytic cleavage is about 1.4fold faster than heterolytic cleavage |
? |
| 5.3.99.4 | 15-oxo-Prostaglandin H2 |
- |
Sus scrofa |
15-oxo-Prostaglandin I2 + ? |
- |
? |
| 5.3.99.4 | 15-oxo-Prostaglandin H2 |
- |
Bos taurus |
15-oxo-Prostaglandin I2 + ? |
- |
? |
| 5.3.99.4 | 5-trans-Prostaglandin H2 |
- |
Sus scrofa |
? |
- |
? |
| 5.3.99.4 | 8-iso-Prostaglandin H2 |
- |
Sus scrofa |
? |
- |
? |
| 5.3.99.4 | 8-iso-Prostaglandin H2 |
- |
Bos taurus |
? |
- |
? |
| 5.3.99.4 | more |
fusion protein linking cyclooxygenase COX-2 and prostacyclin synthase together, is able to convert arachidonic acid to prostaglandin G2, prostaglandin H2 and prostaglandin I2. Fusion protein may directly synthesize prostaglandin I2 from arachidonic acid with Km value of 0.0032 mM |
Homo sapiens |
? |
- |
? |
