EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
    4.3.99.3 | 6-carboxy-5,6,7,8-tetrahydropterin |
- |
Bacillus subtilis |
7-carboxy-7-deazaguanine + NH3 |
- |
? |
| 4.3.99.3 | 6-carboxy-5,6,7,8-tetrahydropterin |
substrate from a coupled reaction with Escherichia coli CPH4 synthase |
Bacillus subtilis |
7-carboxy-7-deazaguanine + NH3 |
- |
? |
| 4.3.99.3 | 6-carboxy-5,6,7,8-tetrahydropterin |
- |
Bacillus subtilis |
7-carboxy-7-carbaguanine + NH3 |
- |
? |
| 4.3.99.3 | 6-carboxy-5,6,7,8-tetrahydropterin |
- |
Escherichia coli |
7-carboxy-7-carbaguanine + NH3 |
- |
? |
| 4.3.99.3 | 6-carboxy-5,6,7,8-tetrahydropterin |
- |
Burkholderia multivorans |
7-carboxy-7-carbaguanine + NH3 |
- |
? |
| 4.3.99.3 | 6-carboxy-5,6,7,8-tetrahydropterin |
the substrate binds perpendicular to the [4Fe-4S]-bound S-adenosyl-L-methionine cofactor, exposing its C6 hydrogen atom for abstraction and generating the binding site for Mg2+, which directly coordinates to the substrate. Substrate binding generates a metal-binding site |
Burkholderia multivorans |
7-carboxy-7-carbaguanine + NH3 |
- |
? |
| 4.3.99.3 | 6-carboxy-5,6,7,8-tetrahydropterin |
the enzyme catalyzes a key step in the biosynthesis of 7-deazapurine containing natural products |
Bacillus subtilis |
7-carboxy-7-carbaguanine + NH3 |
- |
? |
| 4.3.99.3 | 6-carboxy-5,6,7,8-tetrahydropterin |
the key ring-contraction step involves a bridged intermediate rather than a ring-opening one. For the QueE-Mg2+ system, the elimination of ammonia is calculated to be rate limiting, determined by investigation at an atomistic level by using the combined quantum mechanics and molecular mechanics method |
Burkholderia multivorans |
7-carboxy-7-carbaguanine + NH3 |
- |
? |
| 4.3.99.3 | 6-carboxy-5,6,7,8-tetrahydropterin |
- |
Bacillus subtilis 168 |
7-carboxy-7-carbaguanine + NH3 |
- |
? |
| 4.3.99.3 | 6-carboxy-5,6,7,8-tetrahydropterin |
the enzyme catalyzes a key step in the biosynthesis of 7-deazapurine containing natural products |
Bacillus subtilis 168 |
7-carboxy-7-carbaguanine + NH3 |
- |
? |
