EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
  3.6.1.61 | more |
homology modeling techniques shows Glu46, Arg88, and Glu90 are three important determinant residues in binding as they have strong hydrogen bonding interactions and electrostatic interactions with P1,P6-bis(5'-adenosyl)hexaphosphate |
Thermus thermophilus |
? |
- |
? |
| 3.6.1.61 | more |
YgdP does not act on other nucleoside diphosphate derivatives such as ADP-ribose, NADH, UDP-glucose and P1,P3-bis(5'-adenosyl)triphosphate |
Escherichia coli |
? |
- |
? |
| 3.6.1.61 | P1,P4-bis(5'-adenosyl)tetraphosphate + H2O |
- |
Thermus thermophilus |
ATP + AMP |
- |
? |
| 3.6.1.61 | P1,P4-bis(5'-adenosyl)tetraphosphate + H2O |
- |
Escherichia coli |
ATP + AMP |
- |
? |
| 3.6.1.61 | P1,P5-bis(5'-adenosyl)pentaphosphate + H2O |
- |
Thermus thermophilus |
ATP + ADP |
- |
? |
| 3.6.1.61 | P1,P5-bis(5'-adenosyl)pentaphosphate + H2O |
preferred substrate |
Escherichia coli |
ATP + ADP |
- |
? |
| 3.6.1.61 | P1,P6-bis(5'-adenosyl)hexaphosphate + H2O |
- |
Thermus thermophilus |
2 ATP |
- |
? |
| 3.6.1.61 | P1,P6-bis(5'-adenosyl)hexaphosphate + H2O |
hydrolyzed at about 70% compared to P1,P5-bis(5'-adenosyl)pentaphosphate |
Escherichia coli |
2 ATP |
- |
? |
| 3.6.1.61 | P1,P6-bis(5'-adenosyl)hexaphosphate + H2O |
P1,P6-bis(5'-adenosyl)hexaphosphate is the most preferred substrate. Glu46 and Glu50 are conserved residues in the Nudix motif and are involved in catalysis |
Thermus thermophilus |
2 ATP |
- |
? |
