EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.23.17 | beta-lipotropin + H2O |
- |
Bos taurus |
? |
- |
? |
| 3.4.23.17 | Human beta-lipotropin + H2O |
- |
Saccharomyces cerevisiae |
More |
beta-endorphin(1-31) + beta-endorphin(1-29) + beta-endorphin(1-28) + gamma-lipotropin + beta-melanocyte-stimulating hormone |
? |
| 3.4.23.17 | Human beta-lipotropin + H2O |
cleavage at two of the three pairs of basic residues of human beta-lipotropin, at Lys37-Lys38 and Lys57-Arg58, but not at Lys86-Lys87, the cleavage at Lys57-Arg58 occurs primarily between these basic residues |
Bos taurus |
More |
at enzyme concentration of 20 ng/0.1 ml: gamma-lipotropin + a beta-melanotropin linked to beta-endorphin intermediate + beta-endorpin, at enzyme concentration of 40 ng/0.1 ml: complete cleavage to yield beta-endorphin + beta-melanotrophin |
? |
| 3.4.23.17 | Human beta-lipotropin + H2O |
- |
Saccharomyces cerevisiae BJ 3501 |
More |
beta-endorphin(1-31) + beta-endorphin(1-29) + beta-endorphin(1-28) + gamma-lipotropin + beta-melanocyte-stimulating hormone |
? |
| 3.4.23.17 | more |
poorly cleaved: benzyloxycarbonyl-Val-Lys-Lys-Arg 4-methoxy-2-naphthylamide |
Bos taurus |
? |
- |
? |
| 3.4.23.17 | more |
not: Lys-Lys-Arg-Arg residues in ACTH1-39 |
Bos taurus |
? |
- |
? |
| 3.4.23.17 | more |
the enzyme is highly specific for mono- and dibasic residues of prohormones, overview |
Bos taurus |
? |
- |
? |
| 3.4.23.17 | more |
the enzyme is highly specific for mono- and dibasic residues of prohormones |
Bos taurus |
? |
- |
? |
| 3.4.23.17 | NH2-terminal pro-opiomelanocortin1-77 + H2O |
- |
Saccharomyces cerevisiae |
Lys-gamma3-melanotropin + NH2-terminal pro-opiomelanocortin1-49 |
- |
? |
| 3.4.23.17 | NH2-terminal pro-opiomelanocortin1-77 + H2O |
O-linked glycosylation at Thr45 greatly inhibits the ability to cleave the Arg49-Lys50 bond |
Rattus norvegicus |
Lys-gamma3-melanotropin + NH2-terminal pro-opiomelanocortin1-49 |
- |
? |
