EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.22.58 | acetyl-WEHD-7-amido-4-methylcoumarin + H2O |
optimal tetrapeptide recognition motif |
Homo sapiens |
acetyl-WEHD + 7-amino-4-methylcoumarin |
- |
? |
| 3.4.22.58 | CrmA + H2O |
- |
Homo sapiens |
? |
- |
? |
| 3.4.22.58 | interleukin-1beta + H2O |
50 nM enzyme partly cleaves interleukin-1beta into the 28000 Da form and a very faint 17500 Da band can be detected, with other dilutions of TY no cleavage is detected |
Homo sapiens |
? |
- |
? |
| 3.4.22.58 | MDIGAYPHFMPTNLAGDPY + H2O |
- |
Homo sapiens |
AYPHFMPTNLA + AYPHFMPTNLAGD + DIGAYPHFMPTNLAG + IGAYPHFMPTNLAGD + MDIGAYPHFMPTNL + MDIGAYPHFMPTNLA + MDIGAYPHFMPTNLAGD + MDIGAYPHFMPTNLAGDP + Met + MDIG + Met-Asp + Tyr + Pro-Tyr + GDPY + DPY |
quantitative product mass spectrometric analysis, overview |
? |
| 3.4.22.58 | more |
the enzyme fails to process the interleukin-1beta precursor, activity is dependent on the presence of a cysteine residue at position 245 |
Homo sapiens |
? |
- |
? |
| 3.4.22.58 | more |
very little efficiency on caspase-1 substrates |
Homo sapiens |
? |
- |
? |
| 3.4.22.58 | more |
the enzyme cleaves the substrates in the order of increasing efficiency: p35, pro-caspase-3, CrmA |
Homo sapiens |
? |
- |
? |
| 3.4.22.58 | more |
the preferred cleavage sequence is WEHD-/- or LEHD-/- |
Homo sapiens |
? |
- |
? |
| 3.4.22.58 | more |
overexpression induces apoptosis |
Homo sapiens |
? |
- |
? |
| 3.4.22.58 | more |
the enzyme is involved in cytokine activation |
Homo sapiens |
? |
- |
? |
