EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
3.4.21.114 | arterivirus replicase ORF1a + H2O |
cleavage sites are Glu1430/Gly and Glu1452/Ser |
equine arteritis virus |
? |
- |
? |
3.4.21.114 | arterivirus replicase ORF1a + H2O |
ORF1a can be cleaved following two alternative pathways. In the majority nsp3-8 precursors are cleaved at the nsp4/5 site yielding nsp3-4 and nsp5-8. The latter product is then cleaved at nsp7/8 only. In the alternative proteolytic cascade the nsp4/5 site remains uncleaved while the nsp5/6 and nsp6/7 sites are processed. nsp3-8 has to interact with cleaved nsp2 to allow processing of the nsp4/5 junction, when nsp2 cofactor is absent the alternative pathway is used |
equine arteritis virus |
? |
- |
? |
3.4.21.114 | arterivirus replicase ORF1a protein + H2O |
- |
equine arteritis virus |
? |
- |
? |
3.4.21.114 | arterivirus replicase ORF1a protein + H2O |
nsp4 and an unidentified protease is responsible for the cleavage sites nsp2/3, nsp3/4, nsp4/5 and nsp5/6 in the ORF1a protein |
equine arteritis virus |
? |
- |
? |
3.4.21.114 | arterivirus replicase ORF1a protein + H2O |
- |
equine arteritis virus Bucyrus |
? |
- |
? |
3.4.21.114 | arterivirus replicase ORF1ab + H2O |
cleavage sites are the junctions at nsp3/4, Nsp4/5, 2 internal nsp5 sites, nsp5/6, p80/p50, p50/p26, p26/p12, enzyme cleaves between Glu and Gly, Glu and Ser or Glu and Lys |
equine arteritis virus |
? |
- |
? |
3.4.21.114 | arterivirus replicase ORF1ab + H2O |
cleavage sites are the junctions at nsp3/4, Nsp4/5, 2 internal nsp5 sites, nsp5/6, p80/p50, p50/p26, p26/p12, enzyme cleaves between Glu and Gly, Glu and Ser or Glu and Lys |
equine arteritis virus Bucyrus |
? |
- |
? |
3.4.21.114 | arterivirus replicase ORF1b + H2O |
protein is processed by nsp4 serine protease |
equine arteritis virus |
? |
- |
? |
3.4.21.114 | arterivirus replicase ORF1b + H2O |
protein is processed by nsp4 serine protease at the following sites: nsp9/10 i.e. p80/p50, cleavage occurs between Glu2370 and Ser, nsp10/11 i.e. p50/p26, cleavage occurs between Gln2837 and Ser, nsp11/12 i.e. nsp26/p12, cleavage between Glu3056 and Gly |
equine arteritis virus |
? |
- |
? |
3.4.21.114 | arterivirus replicase ORF1b + H2O |
protein is processed by nsp4 serine protease |
equine arteritis virus Bucyrus |
? |
- |
? |