EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
3.1.3.67 | 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H2O |
- |
Homo sapiens |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate |
- |
? |
3.1.3.67 | 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O |
- |
Mus musculus |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate |
- |
? |
3.1.3.67 | 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O |
- |
Homo sapiens |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate |
- |
? |
3.1.3.67 | 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O |
dual-specific phosphatase |
Homo sapiens |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate |
- |
? |
3.1.3.67 | 4-nitrophenyl phosphate + H2O |
- |
Homo sapiens |
4-nitrophenol + phosphate |
- |
? |
3.1.3.67 | D-myo-phosphatidylinositol 3,4,5-trisphosphate + H2O |
- |
Mus musculus |
D-myo-phosphatidylinositol 4,5-bisphosphate + phosphate |
- |
? |
3.1.3.67 | inositol 1,3,4,5-tetrakisphosphate + H2O |
- |
Homo sapiens |
inositol 1,4,5-trisphosphate + phosphate |
- |
? |
3.1.3.67 | more |
the enzyme does not hydrolyze phosphatidylinositol 4,5-bisphosphate |
Bos taurus |
? |
- |
? |
3.1.3.67 | more |
germline PTEN mutations are associated with several dominant growth disorders. The growth regulatory function is primarily mediated via its lipid phosphatase activity, which specifically reduces the cellular levels of phosphatidylinositol 3,4,5-trisphosphate. This activity antagonizes the effects of activated phosphatidylinositol 3-kinase in the nutritionally controlled insulin receptor pathway, thereby reducing protein synthesis and restraining cell and organismal growth, while also regulating other biological processes, such as fertility and ageing. PTEN also plays a role as specialized cytoskeletal regulator, which, for example, is involved in directional movement of some migratory cells and may be important in metastasis |
Homo sapiens |
? |
- |
? |
3.1.3.67 | more |
phosphatase-independent domains of PTEN markedly reduce the invasive potential of glioma cells, defining a structural role for PTEN that regulates cell motility distinct of the PKB/Akt pathway |
Homo sapiens |
? |
- |
? |