EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.7.8.5 | CDP-1,2-diacyl-sn-glycerol + glycerol 3-phosphate |
regulation of enzyme |
Saccharomyces cerevisiae |
? |
- |
? |
2.7.8.5 | CDP-1,2-diacyl-sn-glycerol + glycerol 3-phosphate |
first enzyme of cardiolipin biosynthetic pathway |
Saccharomyces cerevisiae |
? |
- |
? |
2.7.8.5 | CDP-1,2-diacyl-sn-glycerol + glycerol 3-phosphate |
first enzyme of cardiolipin biosynthetic pathway |
Schizosaccharomyces pombe |
? |
- |
? |
2.7.8.5 | CDP-1,2-diacyl-sn-glycerol + glycerol 3-phosphate |
essential for normal cardiolipin content of cells |
Saccharomyces cerevisiae |
? |
- |
? |
2.7.8.5 | CDP-1,2-diacyl-sn-glycerol + glycerol 3-phosphate |
involved in synthesis of phosphatidylglycerol |
Rattus norvegicus |
? |
- |
? |
2.7.8.5 | CDP-1,2-diacyl-sn-glycerol + glycerol 3-phosphate |
the enzyme catalyzes the first committed step in synthesis of cardiolipid. In response to inositol, decrease in Pgs1p enzyme activity is associated with increased phosphorylation of Pgs1p. Phosphorylation of a phospholipid biosynthetic enzyme in response to inositol, new mechanism of inositol-mediated regulation |
Saccharomyces cerevisiae |
CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate |
- |
? |
2.7.8.5 | CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate |
cardiolipin (phospholipid) biosynthesis, regulation by short chain cell-permeable ceramide (C2-Cer: N-acetylsphingosine) signalling and levels of active GTP-bound RhoA |
Cricetulus griseus |
phosphatidylglycerophosphate + CMP |
- |
? |
2.7.8.5 | CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate |
20 min, 30°C, Mes-HCl pH 7, 1 mM Triton X-100, 0.3 mM MnCl2 |
Kluyveromyces lactis |
phosphatidylglycerophosphate + CMP |
- |
? |
2.7.8.5 | CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate |
in vitro assay on mitochondrial fractions of cells grown in presence or absence of 30-50 microM N-acetylsphingosine |
Cricetulus griseus |
phosphatidylglycerophosphate + CMP |
- |
? |
2.7.8.5 | CDP-diacylglycerol + sn-glycero-3-phosphate |
- |
Cricetulus griseus |
CMP + phosphatidylglycerophosphate |
- |
? |