EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
    2.7.7.22 | GDP + alpha-D-mannose 1-phosphate |
- |
Cryptococcus neoformans |
phosphate + GDP-mannose |
- |
? |
| 2.7.7.22 | GDP + alpha-D-mannose 1-phosphate |
- |
Malpighia glabra |
phosphate + GDP-mannose |
- |
? |
| 2.7.7.22 | GDP + alpha-D-mannose 1-phosphate |
GMP catalyzes the synthesis of GDP-mannose, an important step in the formation of all guanosine-containing sugar nucleotides in plants. The GDP-mannose produced by the enzymatic action of GMP plays vital roles in both prokaryotes and eukaryotes, overview. The enzyme activity is correlated to the amount of ascorbic acid, overview |
Malpighia glabra |
phosphate + GDP-mannose |
- |
? |
| 2.7.7.22 | GDPmannose + phosphate |
- |
Saccharomyces cerevisiae |
GDP + mannose 1-phosphate |
- |
? |
| 2.7.7.22 | GDPmannose + phosphate |
- |
Pyrococcus horikoshii |
GDP + mannose 1-phosphate |
- |
r |
| 2.7.7.22 | GDPmannose + phosphate |
reverse reaction involved in synthesis of the compatible solute alpha-mannosylglycerate |
Pyrococcus horikoshii |
GDP + mannose 1-phosphate |
- |
r |
| 2.7.7.22 | more |
diphosphate cannot substitute for phosphate |
Saccharomyces cerevisiae |
? |
- |
? |
| 2.7.7.22 | more |
GDP-mannose, the mannose donor, required for the main cryptococcal virulence factor, a polysaccharide capsule that surrounds the cell, is produced in the cytosol by the sequential actions of phosphomannose isomerase, phosphomannomutase, and GDP-mannose pyrophosphorylase. Cryptococcus neoformans is a fungal pathogen that is responsible for life-threatening disease, particularly in the context of compromised immunity |
Cryptococcus neoformans |
? |
- |
? |
| 2.7.7.22 | more |
GMP is an important enzyme in the Smirnoff-Wheelers pathway for the biosynthesis of ascorbic acid in plants |
Malpighia glabra |
? |
- |
? |
| 2.7.7.22 | more |
the essential enzyme plays a major role in the Smirnoff-Wheelers L-ascorbic acid biosynthetic pathway in plants |
Malpighia glabra |
? |
- |
? |
