EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.6.1.75 | L-aspartic acid + 2-oxoglutarate |
reactivity of isozymes: less than 5% for CAT-I, 15% for CAT-IIA, 42% for CAT-IIB, activity compared to S-(4-bromophenyl)-L-cysteine |
Rattus norvegicus |
oxaloacetate + L-glutamate |
- |
? |
2.6.1.75 | L-cysteine sulfinic acid + 2-oxoglutarate |
reactivity of isozymes: less than 5% for CAT-I, 7% for CAT-IIA, 76% for CAT-IIB, activity compared to S-(4-bromophenyl)-L-cysteine |
Rattus norvegicus |
2-oxo-3-sulfinopropionate + L-glutamate |
- |
? |
2.6.1.75 | L-kynurenine + 2-oxoglutarate |
reactivity of isozymes: 7% for CAT-I, 6% for CAT-IIA, 12% for CAT-IIB, activity compared to S-(4-bromophenyl)-L-cysteine |
Rattus norvegicus |
L-glutamate + 4-(2-aminophenyl)-2,4-dioxobutanoate |
- |
? |
2.6.1.75 | more |
2-oxobutanoate, 2-oxosuccinate and pyruvate exhibit about 3% of activity compared to alpha-ketoglutarate |
Rattus norvegicus |
? |
- |
? |
2.6.1.75 | more |
glyoxylic acid, S-ethyl-L-cysteine, S-2-propyl-L-cysteine, S-cyclohexyl-L-cysteine, S-(2-chloroethyl)-L-cysteine, S-phenyl-L-cysteine sulfoxide are not substrates, negligible activity with other amino acids e.g. L-leucine, L-configuration is essential |
Rattus norvegicus |
? |
- |
? |
2.6.1.75 | more |
isoenzyme CAT-I may be involved in in vivo transamination of cysteine conjugates in rat liver, value of reverse reaction is 5 times lower than forward reaction by CAT-I, forward and reverse reaction at similar rates for CAT-IIA and CAT-IIB |
Rattus norvegicus |
? |
- |
? |
2.6.1.75 | S-(1-butyl)-L-cysteine + 2-oxoglutarate |
reactivity of isozymes: 23% for CAT-I, 30% for CAT-IIA, 33% for CAT-IIB, activity compared to S-(4-bromophenyl)-L-cysteine |
Rattus norvegicus |
S-(1-butyl)-3-thiopyruvate + L-glutamate |
- |
? |
2.6.1.75 | S-(1-propyl)-L-cysteine + 2-oxoglutarate |
reactivity of isozymes: 16% for CAT-I, 13% for CAT-IIA, 14% for CAT-IIB, activity compared to S-(4-bromophenyl)-L-cysteine |
Rattus norvegicus |
S-(1-propyl)-3-thiopyruvate + L-glutamate |
- |
? |
2.6.1.75 | S-(4-bromophenyl)-L-cysteine + 2-oxoglutarate |
highest activity with all three isoenzymes: CAT-I, CAT-IIA, CAT-IIB |
Rattus norvegicus |
S-(4-bromophenyl)-3-thiopyruvate + L-glutamate |
- |
r |
2.6.1.75 | S-(4-bromophenyl)-L-cysteine + 4-methylsulfanyl-2-oxobutanoate |
21% of activity compared to 2-oxoglutarate |
Rattus norvegicus |
S-(4-bromophenyl)-3-thiopyruvate + methionine |
- |
? |