EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
    2.4.2.10 | 5-fluoroorotate + 5-phospho-alpha-D-ribose 1-diphosphate |
- |
Plasmodium falciparum |
? |
- |
? |
| 2.4.2.10 | 5-fluoroorotate + phosphoribose diphosphate |
- |
Saccharomyces cerevisiae |
5-fluoroorotidine 5'-phosphate + diphosphate |
- |
? |
| 2.4.2.10 | 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate |
- |
Homo sapiens |
5-fluorouridine 5'-phosphate + diphosphate |
- |
? |
| 2.4.2.10 | 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate |
essential enzyme for activation of 5-fluorouracil and its derivatives |
Homo sapiens |
5-fluorouridine 5'-phosphate + diphosphate |
- |
? |
| 2.4.2.10 | 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate |
the activating OPRT and its antagonist the catabolizing dihydropyrimidine dehydrogenase play important roles in 5-fluorouracil metabolism, overview |
Homo sapiens |
5-fluorouridine 5'-phosphate + diphosphate |
- |
? |
| 2.4.2.10 | 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate |
the enzyme is involved in degradation of 5-fluorouracil being the key enzyme related to the first-step activation process of 5-fluorouracil, and possibly predicts chemosensitivity to 5-fluorouracil, overview |
Homo sapiens |
5-fluorouridine 5'-phosphate + diphosphate |
- |
? |
| 2.4.2.10 | 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate |
the enzyme is involved in the de novo biosynthesis of pyrimidine nucleotides, main enzyme involved in phosphoribosylation of 5-fluorouracil, an essential step that leads to tumor growth inhibition |
Homo sapiens |
5-fluorouridine 5'-phosphate + diphosphate |
- |
? |
| 2.4.2.10 | 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate |
the enzyme is involved in the metabolism of 5-fluorouracil, a chemotherapeutic drug in treatment of solid cancers, major pathways of 5-fluorouracil metabolism, overview |
Homo sapiens |
5-fluorouridine 5'-phosphate + diphosphate |
- |
? |
| 2.4.2.10 | more |
enzyme from mammals is a bifunctional polypeptide, it also catalyzes the reaction listed as EC 4.1.1.23 |
Mus musculus |
? |
- |
? |
| 2.4.2.10 | more |
enzyme from mammals is a bifunctional polypeptide, it also catalyzes the reaction listed as EC 4.1.1.23 |
Homo sapiens |
? |
- |
? |
