EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   2.4.1.227 | dUDP-N-acetyl-alpha-D-glucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol |
- |
Escherichia coli |
? |
- |
? |
| 2.4.1.227 | more |
- |
Escherichia coli |
? |
- |
? |
| 2.4.1.227 | more |
MurG binds significantly better to UDP than to CDP, ADP or GDP, E269 is an important residue in binding the nucleotide-sugar donor |
Escherichia coli |
? |
- |
? |
| 2.4.1.227 | more |
MurG requires substrates containing an intact amide between the muramyl lactyl ether side-chain and the pentapeptide |
Escherichia coli |
? |
- |
? |
| 2.4.1.227 | more |
no substrates: TDP-GlcNAc, C4 hydroxyl of UDP-GalNAc cannot form hydrogen bonds to A264 or N292 |
Escherichia coli |
? |
- |
? |
| 2.4.1.227 | more |
MurG prefers substrates that contain lipid chains that are considerably shorter than that of the natural substrate, compounds that contain a cis-allylic double bond react faster than compounds that do not |
Escherichia coli |
? |
- |
? |
| 2.4.1.227 | more |
no substrates: P1-citronellyl-P2-alpha-D-glucosyl pyrophosphate, P1-citronellyl-P2-alpha-D-N-acetylglucoseaminyl pyrophosphate, P1-citronellyl-P2-alpha-D-N-acetylmuramyl pyrophosphate |
Escherichia coli |
? |
- |
? |
| 2.4.1.227 | more |
role of enzyme in peptidoglycan biosynthesis pathway |
Escherichia coli |
? |
- |
? |
| 2.4.1.227 | more |
UDP-N-acetylgalactosamine shows very little donor activity |
Escherichia coli |
? |
- |
? |
| 2.4.1.227 | more |
sMurG uses UDP-N-acetylglucosamine as substrate |
Clostridioides difficile |
? |
- |
? |
