EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.4.1.22 | alpha-UDP-D-galactose + D-glucose |
inversion of anomeric configuration to form beta-O-galactosides |
Bos taurus |
UDP + lactose |
- |
? |
2.4.1.22 | alpha-UDP-D-galactose + N-acetyl-D-glucosamine |
- |
Bos taurus |
UDP + alpha-D-galactosyl(1-4)beta-N-acetyl-D-glucosamine |
- |
? |
2.4.1.22 | dUDPgalactose + D-glucose |
- |
Mammalia |
lactose + dUDP |
- |
? |
2.4.1.22 | dUDPgalactose + D-glucose |
- |
Bos taurus |
lactose + dUDP |
- |
? |
2.4.1.22 | dUDPgalactose + D-glucose |
dUDPgalactose is 80% as effective as UDP-D-galactose |
Bos taurus |
lactose + dUDP |
- |
? |
2.4.1.22 | more |
acceptor substrate specificity, overview |
Bos taurus |
? |
- |
? |
2.4.1.22 | more |
upon substrate binding to beta4Gal-T1, a large conformational change occurs in the region comprising residues 345 to 365. The role of alpha-lactalbumin is to hold glucose by hydrogen bonding with the O-1 hydroxyl group in the acceptor-binding site on beta4Gal-T1, while the N-acetyl group-binding pocket in beta4Gal-T1 adjusts to maximize the interactions with the glucose molecule |
Mus musculus |
? |
- |
? |
2.4.1.22 | more |
upon substrate binding to beta4Gal-T1, a large conformational change occurs in the region comprising residues 345 to 365. The role of alpha-lactalbumin is to hold glucose by hydrogen bonding with the O-1 hydroxyl group in the acceptor-binding site on beta4Gal-T1, while the N-acetyl group-binding pocket in beta4Gal-T1 adjusts to maximize the interactions with the glucose molecule |
Bos taurus |
? |
- |
? |
2.4.1.22 | more |
acceptor substrate specificity, no activity with D-galactose, N-acetylgalactosamine, glucosamine, and lactose as acceptor substrates, no activity with UDP-glucose as donor substrate, overview |
Helicobacter pylori |
? |
- |
? |
2.4.1.22 | more |
acceptor substrate specificity, no activity with D-galactose, N-acetylgalactosamine, glucosamine, and lactose as acceptor substrates, overview |
Neisseria meningitidis |
? |
- |
? |