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Results 1 - 9 of 9
EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Show all pathways known for 2.3.1.94Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.946 methylmalonyl-CoA + propionyl-CoA + 6 NADPH + 6 H+ - Saccharopolyspora erythraea 6-deoxyerythronolide b + 7 CoA + 6 CO2 + H2O + 6 NADP+ - ?
Show all pathways known for 2.3.1.94Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.946 methylmalonyl-CoA + propionyl-CoA + 6 NADPH + 6 H+ formation of a key intermediate in the biosynthesis of erythromycin Saccharopolyspora erythraea 6-deoxyerythronolide b + 7 CoA + 6 CO2 + H2O + 6 NADP+ - ?
Show all pathways known for 2.3.1.94Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.94more unidirectional translocation of the growing polyketide chain along the 6-deoxyerythronolide B synthase, ratchet mechanism, overview Saccharopolyspora erythraea ? - ?
Show all pathways known for 2.3.1.94Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.94more the cis-acyltransferase domain from DEBS module 3 transfers a methylmalonyl extender unit from the corresponding carboxyacyl-CoA precursor onto the phosphopantetheine arm of the acyl carrier protein within the same module. The presence of the acyl carrier protein has little effect on the specificity of the cis-acyltransferase domain for carboxyacyl-CoA substrates, but has a marked influence on the corresponding specificity parameters for the trans-acyltransferases from the disorazole and kirromycin synthases. Comparative analysis of the substrate specificity Saccharopolyspora erythraea ? - ?
Show all pathways known for 2.3.1.94Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.94propanoyl-CoA + (2S)-methylmalonyl-CoA + NADPH - Saccharopolyspora erythraea (3R,4S,5R,6R)-6-ethyl-4-hydroxy-3,5-dimethyloxan-2-one + ? - ?
Show all pathways known for 2.3.1.94Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.94propanoyl-CoA + 5 (2S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 6 NADPH + 6 H+ - Saccharopolyspora erythraea (3R,4S,5R,6R)-6-ethyl-4-hydroxy-3,5-dimethyltetrahydro-2H-pyran-2-one + ? product of truncated enzyme consisting of loading didomain-module1-module2+thioesterase ?
Show all pathways known for 2.3.1.94Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.94propanoyl-CoA + 5 (2S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 6 NADPH + 6 H+ - Saccharopolyspora erythraea (3R,5R,6S)-6-[(2S,3R)-3-hydroxypentan-2-yl]-3,5-dimethyldihydro-2H-pyran-2,4(3H)-dione + ? product of truncated enzyme consisting of loading didomain-module1-module2-module3+thioesterase ?
Show all pathways known for 2.3.1.94Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.94propanoyl-CoA + 5 (2S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 6 NADPH + 6 H+ - Saccharopolyspora erythraea 8-ethyl-8-desmethyl-6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+ putative analog, 8-ethyl-8-desmethyl-6-deoxyerythronolide B, is generated by the assembly line in the presence of non-limiting concentrations of ethylmalonyl-CoA and is produced in comparable amounts to the natural 6-dEB product ?
Show all pathways known for 2.3.1.94Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.94propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+ - Saccharopolyspora erythraea 6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+ - ?
Results 1 - 9 of 9