EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.3.1.241 | a dodecanoyl-[acyl-carrier protein] + (3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-hydroxytetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose |
- |
Escherichia coli |
(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose + an [acyl-carrier protein] |
- |
? |
2.3.1.241 | a dodecanoyl-[acyl-carrier protein] + (3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-hydroxytetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose |
- |
Cronobacter sakazakii |
(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose + an [acyl-carrier protein] |
LpxL transfers a C14:0 secondary acyl chain to the 2'-position of lipid A |
? |
2.3.1.241 | a dodecanoyl-[acyl-carrier protein] + (3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-hydroxytetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose |
i.e. alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA |
Escherichia coli |
(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose + an [acyl-carrier protein] |
- |
? |
2.3.1.241 | a dodecanoyl-[acyl-carrier protein] + (3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-hydroxytetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose |
the purified enzyme rapidly incorporates one dodecanoate into alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA. The rate of dodecanoate incorporation is reduced by several orders of magnitude when either one or both Kdos are absent in the acceptor. The enzyme incorporates dodecanoate 38 times faster than decanoate or tetradecanoate, respectively. Transfer of palmitate, palmitoleate, or R-3-hydroxymyristate is very slow |
Escherichia coli |
(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose + an [acyl-carrier protein] |
- |
? |
2.3.1.241 | a dodecanoyl-[acyl-carrier protein] + (3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-hydroxytetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose |
- |
Cronobacter sakazakii ATCC BAA-894 |
(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose + an [acyl-carrier protein] |
LpxL transfers a C14:0 secondary acyl chain to the 2'-position of lipid A |
? |
2.3.1.241 | a dodecanoyl-[acyl-carrier protein] + Kdo2-lipid IVA |
- |
Klebsiella pneumoniae |
dodecanoyl-Kdo2-lipid IVA + an [acyl-carrier protein] |
- |
? |
2.3.1.241 | a dodecanoyl-[acyl-carrier protein] + Kdo2-lipid IVA |
acyltransferase encoded by PP_1735 catalyses the addition of the C12:0 chain to the 2'-position of lipid A in Pseudomonas putida |
Pseudomonas putida |
dodecanoyl-Kdo2-lipid IVA + an [acyl-carrier protein] |
- |
? |
2.3.1.241 | a dodecanoyl-[acyl-carrier protein] + Kdo2-lipid IVA |
LpxL1 transfers a C12:0 acyl chain to the 2-O at the (3R)-hydroxytetradecanoyl chain on the 2'-glucosaminyl moity of Kdo2-lipid IVA |
Klebsiella pneumoniae |
dodecanoyl-Kdo2-lipid IVA + an [acyl-carrier protein] |
- |
? |
2.3.1.241 | a dodecanoyl-[acyl-carrier protein] + Kdo2-lipid IVA |
LpxL1 transfers a C12:0 acyl chain to the 2-O at the (3R)-hydroxytetradecanoyl chain on the 2'-glucosaminyl moity of Kdo2-lipid IVA |
Klebsiella pneumoniae 342 |
dodecanoyl-Kdo2-lipid IVA + an [acyl-carrier protein] |
- |
? |
2.3.1.241 | a tetradecanoyl-[acyl-carrier protein] + Kdo2-lipid IVA |
- |
Klebsiella pneumoniae |
tetradecanoyl-Kdo2-lipid IVA + an [acyl-carrier protein] |
- |
? |