EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.3.1.238 | (S)-2-methylbutanoyl-N-acetylcysteamine + 6-hydroxy-6-demethylmonacolin J |
- |
Aspergillus terreus |
pravastatin + N-acetylcysteamine |
- |
? |
2.3.1.238 | (S)-2-methylbutanoyl-N-acetylcysteamine + monacolin J |
- |
Aspergillus terreus |
lovastatin + N-acetylcysteamine |
- |
? |
2.3.1.238 | alpha-dimethylbutanoyl-N-acetylcysteamine + 6-hydroxy-6-demethylmonacolin J |
- |
Aspergillus terreus |
huvastatin + N-acetylcysteamine |
- |
? |
2.3.1.238 | alpha-dimethylbutanoyl-N-acetylcysteamine + monacolin J |
- |
Aspergillus terreus |
simvastatin + N-acetylcysteamine |
- |
? |
2.3.1.238 | benzoyl-CoA + monacolin J |
- |
Aspergillus terreus |
? + CoA |
- |
? |
2.3.1.238 | butanoyl-N-acetylcysteamine + monacolin J |
- |
Aspergillus terreus |
(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl butanoate + N-acetylcysteamine |
- |
? |
2.3.1.238 | butyryl-CoA + monacolin J |
87% conversion after 10 h |
Aspergillus terreus |
(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl butanoate + CoA |
- |
? |
2.3.1.238 | hexanoyl-N-acetylcysteamine + monacolin J |
- |
Aspergillus terreus |
? + N-acetylcysteamine |
- |
? |
2.3.1.238 | monacolin J acid + (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] |
- |
Aspergillus terreus |
lovastatin acid + [2-methylbutanoate polyketide synthase] |
- |
? |
2.3.1.238 | monacolin J acid + (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] |
the enzyme is involved in lovastatin biosynthesis |
Aspergillus terreus |
lovastatin acid + [2-methylbutanoate polyketide synthase] |
- |
? |