EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.3.1.220 | 2 malonyl-CoA + benzoyl-CoA |
reaction of mutant T135L, no activity with the wild-type enzyme. The T135L mutant adds only two acetyl groups to the benzoyl starter unit to form a triketide intermediate which then cyclized into 6-phenyl-4-hydroxy-2-pyrone via C5 keto-enol oxygen -> C1 lactonization |
Hypericum androsaemum |
3 CoA + 6-phenyl-4-hydroxy-2-pyrone + 2 CO2 |
- |
? |
2.3.1.220 | 2 malonyl-CoA + benzoyl-CoA |
reaction of mutant T135L, no activity with the wild-type enzyme. The T135L mutant adds only two acetyl groups to the benzoyl starter unit to form a triketide intermediate which then cyclized into 6-phenyl-4-hydroxy-2-pyrone via C5 keto-enol oxygen -> C1 lactonization |
Sorbus aucuparia |
3 CoA + 6-phenyl-4-hydroxy-2-pyrone + 2 CO2 |
- |
? |
2.3.1.220 | 3 malonyl-CoA + 3-hydroxybenzoyl-CoA |
43.5% of the activity compared to benzoyl-CoA |
Hypericum perforatum |
4 CoA + 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 |
- |
? |
2.3.1.220 | 3 malonyl-CoA + benzoyl-CoA |
- |
Hypericum androsaemum |
4 CoA + 2,4,6-trihydroxybenzophenone + 3 CO2 |
- |
? |
2.3.1.220 | 3 malonyl-CoA + benzoyl-CoA |
- |
Sorbus aucuparia |
4 CoA + 2,4,6-trihydroxybenzophenone + 3 CO2 |
- |
? |
2.3.1.220 | 3 malonyl-CoA + benzoyl-CoA |
- |
Scutellaria baicalensis |
4 CoA + 2,4,6-trihydroxybenzophenone + 3 CO2 |
- |
? |
2.3.1.220 | 3 malonyl-CoA + benzoyl-CoA |
- |
Hypericum perforatum |
4 CoA + 2,4,6-trihydroxybenzophenone + 3 CO2 |
- |
? |
2.3.1.220 | 3 malonyl-CoA + benzoyl-CoA |
- |
Garcinia mangostana |
4 CoA + 2,4,6-trihydroxybenzophenone + 3 CO2 |
- |
? |
2.3.1.220 | 3 malonyl-CoA + benzoyl-CoA |
- |
Hoppea fastigiata |
4 CoA + 2,4,6-trihydroxybenzophenone + 3 CO2 |
- |
? |
2.3.1.220 | 3 malonyl-CoA + benzoyl-CoA |
a minor amount of tetraketide lactone and triketide lactone are also obtained |
Garcinia mangostana |
4 CoA + 2,4,6-trihydroxybenzophenone + 3 CO2 |
- |
? |