EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.3.1.194 | 2 malonyl-CoA |
- |
Streptomyces sp. |
acetoacetyl-CoA + CoA + 2 CO2 |
- |
? |
2.3.1.194 | acetyl-CoA + malonyl-CoA |
- |
Streptomyces sp. |
acetoacetyl-CoA + CoA + CO2 |
- |
? |
2.3.1.194 | acetyl-CoA + malonyl-CoA |
- |
Streptomyces sp. CL190 |
acetoacetyl-CoA + CoA + CO2 |
- |
ir |
2.3.1.194 | acetyl-CoA + malonyl-CoA |
- |
Streptomyces glaucescens |
acetoacetyl-CoA + CoA + CO2 |
- |
ir |
2.3.1.194 | acetyl-CoA + malonyl-CoA |
the acetoacetyl-CoA synthesizing enzyme increases the acetoacetyl-CoA supply for mevalonate production |
Streptomyces sp. |
acetoacetyl-CoA + CoA + CO2 |
- |
? |
2.3.1.194 | acetyl-CoA + malonyl-CoA |
Cys115 in NphT7 functions as a key catalytic residue for the condensation reaction. His256 functions as a catalytic residue for the decarboxylation of the extender substrate malonyl-CoA. No acetoacetyl-CoA synthesizing activity is detected through the condensation of two molecules of acetyl-CoA |
Streptomyces sp. |
acetoacetyl-CoA + CoA + CO2 |
- |
? |
2.3.1.194 | acetyl-CoA + malonyl-CoA |
- |
Streptomyces sp. |
CoA + acetoacetyl-CoA + CO2 |
- |
ir |
2.3.1.194 | more |
the recombinant enzyme catalyzes a single condensation of acetyl-CoA and malonyl-CoA to give acetoacetyl-CoA and CoA. Replacement of malonyl-CoA with malonyl-(acyl carrier protein) results in loss of the condensation activity. No acetoacetyl-CoA synthesizing activity detectable through the condensation of two molecules of acetyl-CoA |
Streptomyces sp. |
? |
- |
? |