EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.1.3.12 | 2 carbamoyl phosphate + N,N'-bis(7-[[(2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl)-3-methyl-1H-pyrrole-2,4-dicarboxamide |
the tandem action of CouL, CouM, CouP, and NovN generates a biscarbamoyl analogue of the pseudodimer coumermycin A1 |
Streptomyces niveus |
2 phosphate + (3-methyl-1H-pyrrole-2,4-diyl)bis[carbonylimino(4-hydroxy-8-methyl-2-oxo-2H-chromene-3,7-diyl)oxy-(2R,3R,4S,5R)-3-hydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2,4-diyl] dicarbamate |
- |
? |
2.1.3.12 | carbamoyl phosphate + decarbamoylnovobiocin |
- |
Streptomyces niveus |
phosphate + novobiocin |
- |
? |
2.1.3.12 | carbamoyl phosphate + decarbamoylnovobiocin |
the enzyme is involved in the biosynthesis of the aminocoumarin antibiotics, novobiocin |
Streptomyces niveus |
phosphate + novobiocin |
- |
? |
2.1.3.12 | carbamoyl phosphate + decarbamoylnovobiocin |
NovN is specific for carbamoyl phosphate as substrate. With acetyl phosphate, no product formation is observed |
Streptomyces niveus |
phosphate + novobiocin |
- |
? |
2.1.3.12 | carbamoyl phosphate + novclobiocin 104 |
87% of novclobiocin 104 is converted to the carbamoylated derivative after overnight incubation |
Streptomyces niveus |
phosphate + ? |
- |
? |
2.1.3.12 | carbamoyl phosphate + novclobiocin 105 |
- |
Streptomyces niveus |
phosphate + novclobiocin 115 |
- |
? |
2.1.3.12 | carbamoyl phosphate + novclobiocin 107 |
- |
Streptomyces niveus |
phosphate + novclobiocin 117 |
- |
? |
2.1.3.12 | carbamoyl phosphate + novclobiocin 108 |
- |
Streptomyces niveus |
phosphate + novclobiocin 118 |
- |
? |
2.1.3.12 | carbamoyl phosphate + novclobiocin 283 |
- |
Streptomyces niveus |
phosphate + novclobiocin 284 |
- |
? |