EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.1.2.1 | (6S)-tetrahydrofolate + D-serine |
- |
Plasmodium falciparum |
5,10-methylenetetrahydrofolate + glycine + H2O |
- |
r |
2.1.2.1 | (6S)-tetrahydrofolate + D-serine |
- |
Plasmodium vivax |
5,10-methylenetetrahydrofolate + glycine + H2O |
- |
r |
2.1.2.1 | (6S)-tetrahydrofolate + D-serine |
poor activity |
Homo sapiens |
5,10-methylenetetrahydrofolate + glycine + H2O |
- |
r |
2.1.2.1 | (6S)-tetrahydrofolate + L-serine |
- |
Plasmodium falciparum |
5,10-methylenetetrahydrofolate + glycine + H2O |
- |
r |
2.1.2.1 | (6S)-tetrahydrofolate + L-serine |
- |
Plasmodium vivax |
5,10-methylenetetrahydrofolate + glycine + H2O |
- |
r |
2.1.2.1 | (6S)-tetrahydrofolate + L-serine |
- |
Homo sapiens |
5,10-methylenetetrahydrofolate + glycine + H2O |
- |
r |
2.1.2.1 | (6S)-tetrahydrofolate + L-serine |
the enzyme also catalyzes the formation of methylene-tetrahydromethanopterin from tetrahydromethanopterin and L-serine, albeit with a catalytic efficiency which is less than 1% of that with (6S)-tetrahydrofolate as substrate. The catalytic efficiency with methylene-tetrahydrosarcinapterin as substrate is even lower |
Methanosarcina barkeri |
5,10-methylenetetrahydrofolate + glycine + H2O |
- |
? |
2.1.2.1 | (6S)-tetrahydrofolate + L-serine |
the enzyme also catalyzes the formation of methylene-tetrahydromethanopterin from tetrahydromethanopterin and L-serine, albeit with a catalytic efficiency which is less than 1% of that with (6S)-tetrahydrofolate as substrate. The catalytic efficiency with methylene-tetrahydrosarcinapterin as substrate is even lower |
Methanosarcina barkeri DSM 804 |
5,10-methylenetetrahydrofolate + glycine + H2O |
- |
? |
2.1.2.1 | 5,10-methenyl-tetrahydropteroyl pentaglutamate + glycine + H2O |
- |
Homo sapiens |
5-formyl-tetrahydropteroyl pentaglutamate + L-serine |
- |
? |
2.1.2.1 | 5,10-methenyl-tetrahydropteroyl pentaglutamate + glycine + H2O |
- |
Oryctolagus cuniculus |
5-formyl-tetrahydropteroyl pentaglutamate + L-serine |
- |
? |