EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   2.1.1.64 | more |
wide substrate specificity. The enzyme methylates both eukaryotic substrates 3,4-dihydroxy-5-farnesylbenzoic acid (this activity is classified as EC 2.1.1.114) and demethylubiquinol-3 and the distinct prokaryotic substrate 3-((2E,6E)-farnesyl)benzene-1,2-diol |
Homo sapiens |
? |
- |
? |
| 2.1.1.64 | S-adenosyl-L-methionine + 3-demethylubiquinol-10 |
the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-10, 1. the methylation of 3,4-dihydroxy-5-all-trans-decaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-10 |
Homo sapiens |
S-adenosyl-L-homocysteine + ubiquinol-10 + H+ |
- |
? |
| 2.1.1.64 | S-adenosyl-L-methionine + 3-demethylubiquinol-3 |
i.e. 5-((2E,6E)-farnesyl)-2-hydroxy-3-methoxy-6-methyl-1,4-benzoquinone |
Escherichia coli |
S-adenosyl-L-homocysteine + ubiquinol-3 |
- |
? |
| 2.1.1.64 | S-adenosyl-L-methionine + 3-demethylubiquinol-3 |
i.e. 5-(2E,6E)-farnesyl-2-hydroxy-3-methoxy-6-methyl-1,4-benzoquinone |
Escherichia coli |
S-adenosyl-L-homocysteine + ubiquinol-3 |
- |
? |
| 2.1.1.64 | S-adenosyl-L-methionine + 3-demethylubiquinol-3 |
i.e. 5-(2E,6E)-farnesyl-2-hydroxy-3-methoxy-6-methyl-1,4-benzoquinone |
Saccharomyces cerevisiae |
S-adenosyl-L-homocysteine + ubiquinol-3 |
- |
? |
| 2.1.1.64 | S-adenosyl-L-methionine + 3-demethylubiquinol-3 |
i.e. 5-(2E,6E)-farnesyl-2-hydroxy-3-methoxy-6-methyl-1,4-benzoquinone, in vitro assay |
Homo sapiens |
S-adenosyl-L-homocysteine + ubiquinol-3 |
- |
? |
| 2.1.1.64 | S-adenosyl-L-methionine + 3-demethylubiquinol-3 |
i.e. 5-(2E,6E)-farnesyl-2-hydroxy-3-methoxy-6-methyl-1,4-benzoquinone, in vitro assay |
Rattus norvegicus |
S-adenosyl-L-homocysteine + ubiquinol-3 |
- |
? |
| 2.1.1.64 | S-adenosyl-L-methionine + 3-demethylubiquinol-6 |
the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-6 in Saccharomyces cerevisiae, 1. the methylation of 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate (this reaction is classified as EC 2.1.1.114) and 2. the methylation of 3-demethylubiquinol-6 |
Saccharomyces cerevisiae |
S-adenosyl-L-homocysteine + ubiquinol-6 |
- |
? |
| 2.1.1.64 | S-adenosyl-L-methionine + 3-demethylubiquinol-6 |
3-demethylubiquinol-6 is an intermediate in biosynthesis of ubiquinone-6 in Saccharomyces cerevisiae (methylated by the yeast enzyme COQ3 to ubiquinol-6). The human construct rescues the growth of a yeast coq3 null mutant on a nonfermentable carbon source and restores coenzyme Q biosynthesis, although at lower levels than that of wild type yeast |
Homo sapiens |
S-adenosyl-L-homocysteine + ubiquinol-6 |
- |
? |
| 2.1.1.64 | S-adenosyl-L-methionine + 3-demethylubiquinol-8 |
involved in biosynthesis of ubiquinone-8 |
Escherichia coli |
S-adenosyl-L-homocysteine + ubiquinol-8 |
- |
? |
