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Results 1 - 10 of 10
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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the reaction diagram Show all sequences 2.1.1.308(2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin - Streptomyces wedmorensis (S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin - ?
Display the reaction diagram Show all sequences 2.1.1.308(2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin Fom3 catalyzes the penultimate step in the biosynthesis of fosfomycin, an antibiotic produced by several species of Streptomyces and Pseudomonas Streptomyces fradiae (S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin - ?
Display the reaction diagram Show all sequences 2.1.1.308(2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin the enzyme is required for fosfomycin production Streptomyces fradiae (S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin - ?
Display the reaction diagram Show all sequences 2.1.1.308(2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin (S)- and (R)-(2-hydroxy[1-2H1]ethyl)phosphonic acids are fed to Streptomyces fradiae. The deuterium of (R)-(2-hydroxy[1-2H1]ethyl)phosphonic acid is lost, and the deuterium of (S)-(2-hydroxy[1-2H1]ethyl)phosphonic acid is retained on incorporation into fosfomycin Streptomyces fradiae (S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin - ?
Display the reaction diagram Show all sequences 2.1.1.308(2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin C-2 methylation of hydroxyethyl phosphonate Streptomyces fradiae (S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin - ?
Display the reaction diagram Show all sequences 2.1.1.308(2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin incorporation of 18O in the alcohol function of 18O-labeled HEP into the FM molecule but not of 18O2 gas Streptomyces fradiae (S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin - ?
Display the reaction diagram Show all sequences 2.1.1.308(2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin no activity with (R)-2-hydroxyethylphosphonate Streptomyces fradiae (S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin - ?
Display the reaction diagram Show all sequences 2.1.1.308(2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin when (R)- and (S)-2-hydroxyethylphosphonate are fed to Streptomyces fradiae producing fosfomycin, only (S)-2-hydroxyethylphosphonate is efficiently incorporated into fosfomycin (37% deuterium at C-1 of the aminophosphonic acid) Streptomyces fradiae (S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin - ?
Display the reaction diagram Show all sequences 2.1.1.308S-adenosyl-L-methionine + methylcob(III)alamin + 2-hydroxyethylphosphonate - Streptomyces wedmorensis 5'-deoxyadenosine + L-methionine + cob(III)alamin + (2S)-2-hydroxypropylphosphonate - ?
Display the reaction diagram Show all sequences 2.1.1.308S-adenosyl-L-methionine + methylcob(III)alamin + 2-hydroxyethylphosphonate the enzyme is involved in the biosynthesis of the broad-spectrum antibiotic fosfomycin Streptomyces wedmorensis 5'-deoxyadenosine + L-methionine + cob(III)alamin + (2S)-2-hydroxypropylphosphonate - ?
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