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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.203more NSun2 catalyzes the formation of cytosine-5 methylation in several tRNAs in vivo in tissues, including skin, liver, and testis Mus musculus ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.203more the Nsun2 fabricate 5-methylcytosine (m5C) in RNA molecules utilizing a dual-cysteine catalytic mechanism Mammalia ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.203more the enzyme forms covalent complexes with previously methylated RNA requiring S-adenosyl-L-homocysteine, the removal of this metabolite results in the disassembly of preexisting complexes Mammalia ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.203more levels of m5C changes site-specifically and dynamically in response to oxidative stress. All individual m5C sites showing significantly different methylation levels in NSUN2-rescued cells after 2 or 4 hours of stress. Methylation levels within the same tRNA molecule are independent from each other Homo sapiens ? - -
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.203more NSUN2-methylated tRNA sites are located in the anticodon loop (C34) and the VL (C46, C47), number of m5C per tRNA in all tRNAs or tRNA leucine, mass spectrometry, overview Homo sapiens ? - -
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.203more the presence of a stable anticodon stem is found to be essential for formation of m5C34 of mt-tRNAMet by NSUN3 Saccharomyces cerevisiae ? - -
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.203S-adenosyl-L-methionine + cytidine34 in mitochondrial tRNA - Homo sapiens S-adenosyl-L-homocysteine + 5-methylcytidine34 in mitochondrial tRNA - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.203S-adenosyl-L-methionine + cytosine34 in mitochondrial tRNAMet precursor - Homo sapiens S-adenosyl-L-homocysteine + 5-methylcytosine34 in mitochondrial tRNAMet precursor - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.203S-adenosyl-L-methionine + cytosine34 in mitochondrial tRNAMet precursor - Saccharomyces cerevisiae S-adenosyl-L-homocysteine + 5-methylcytosine34 in mitochondrial tRNAMet precursor - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.203S-adenosyl-L-methionine + cytosine34 in mitochondrial tRNAMet(AUA) precursor - Homo sapiens S-adenosyl-L-homocysteine + 5-methylcytosine34 in mitochondrial tRNAMet(AUA) precursor - ?
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