EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.8.98.2 | 2-Cys peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + GSH |
- |
Pisum sativum |
2-Cys peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + GSSG |
- |
? |
1.8.98.2 | more |
no activity with CTP, UTP, dCTP, or dTTP |
Homo sapiens |
? |
- |
? |
1.8.98.2 | more |
catalyzes the reduction of cysteine sulfinic acid to sulfenic acid in oxidized proteins and protects them from inactivation |
Mus musculus |
? |
- |
? |
1.8.98.2 | more |
catalyzes the reduction of cysteine sulfinic acid to sulfenic acid in oxidized proteins and protects them from inactivation |
Homo sapiens |
? |
- |
? |
1.8.98.2 | more |
catalyzes the deglutathionylation of actin |
Homo sapiens |
? |
- |
? |
1.8.98.2 | more |
promotes the reversal of cysteine modified PTP1B to its reduced and enzymatically active form |
Homo sapiens |
? |
- |
? |
1.8.98.2 | more |
reduction of cysteine sulfinic acid to sulfenic acid in proteins subject to oxidative stress |
Homo sapiens |
? |
- |
? |
1.8.98.2 | more |
assay conditions optimization, overview |
Arabidopsis thaliana |
? |
- |
? |
1.8.98.2 | more |
enzyme is able to act as a redox-dependent sulfinic acid reductase and as a redox-independent nuclease enzyme. Sulfiredoxin functions as a nuclease enzyme that can use single-stranded and double-stranded DNAs as substrates. The active site of the reductase function of sulfiredoxin is not involved in its nuclease function |
Arabidopsis thaliana |
? |
- |
? |
1.8.98.2 | more |
AtSrx has sulfinic acid reductase activity to catalyze the reduction of the overoxidized form of 2-Cys Prx in vitro and in vivo |
Arabidopsis thaliana |
? |
- |
- |