EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
    1.8.4.12 | (R)-methyl 4-tolyl sulfoxide + thioredoxin |
- |
Homo sapiens |
? |
- |
? |
| 1.8.4.12 | (S)-1-nonen-4-ol + thioredoxin |
- |
Neisseria meningitidis |
? |
- |
r |
| 1.8.4.12 | acetyl-L-methionine (R)-sulfoxide methyl ester + thioredoxin |
the affinity of MsrB to acetyl-L-methionine (R)-sulfoxide methyl ester is higher than to L-methionine (R)-sulfoxide |
Neisseria meningitidis |
L-methionine methyl ester + thioredoxin disulfide + H2O |
- |
? |
| 1.8.4.12 | acetyl-L-methionine (R)-sulfoxide N-methyl ester + thioredoxin |
- |
Neisseria meningitidis |
L-methionine methyl ester + thioredoxin disulfide + H2O |
- |
r |
| 1.8.4.12 | acetyl-L-methionine-(R)-S-oxide-NHMe + thioredoxin |
- |
Neisseria meningitidis |
? |
- |
? |
| 1.8.4.12 | calmodulin-L-methionine (R)-S-oxide + thioredoxin |
MsrBA is able to completely reduce (i.e., repair) MetSO in the calcium regulatory protein calmodulin. The efficient repair is the coordinate activity of the two catalytic domains in the MsrBA fusion protein, which results in a 1 order of magnitude rate enhancement in comparison to those of the individual MsrA or MsrB enzyme alone |
Shewanella oneidensis |
calmodulin-L-methionine + thioredoxin disulfide + H2O |
- |
? |
| 1.8.4.12 | calmodulin-L-methionine (R)-sulfoxide + thioredoxin |
- |
Escherichia coli |
calmodulin-L-methionine + thioredoxin disulfide + H2O |
- |
? |
| 1.8.4.12 | calmodulin-L-methionine (R)-sulfoxide + thioredoxin |
MsrB is specific for the R-form, enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues, which restores the calmodulin binding to adenylate cyclase of the pathogen Bordetella pertussis, which is an essential step for the bacterium to enter host cells, overview |
Homo sapiens |
calmodulin-L-methionine + thioredoxin disulfide + H2O |
- |
? |
| 1.8.4.12 | calmodulin-L-methionine (R)-sulfoxide + thioredoxin |
MsrB is specific for the R-form, recombinant human calmodulin, recombinant human enzyme, artificial system, determination of oxidized methionine residues being reduced by the enzyme, overview |
Homo sapiens |
calmodulin-L-methionine + thioredoxin disulfide + H2O |
- |
? |
| 1.8.4.12 | dabsyl L-methionine (R)-sulfoxide + thioredoxin |
cytosolic human thioredoxin 1, mitochondrial rat thioredoxin 2 lacking a mitochondrial signal peptide or Escherichia coli thioredoxin |
Mus musculus |
dabsyl L-methionine + thioredoxin disulfide + H2O |
- |
? |
