EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   1.5.1.33 | 2 biopterin + 3 NADPH + 3 H+ |
essential enzyme of pterin and folate metabolism |
Leishmania donovani |
dihydrobiopterin + tetrahydrobiopterin + 3 NADP+ |
- |
? |
| 1.5.1.33 | 2 biopterin + 3 NADPH + 3 H+ |
salvage of pterins, enzyme acts as a metabolic bypass for drugs targeting dihydrofolate reductase, PTR1 contributes about 10% of the reduction of folates in wild-type cells while the remaining 90% is due to the activity of dihydrofolate reductase-thymidylate synthase (EC 1.5.1.3) |
Leishmania donovani |
dihydrobiopterin + tetrahydrobiopterin + 3 NADP+ |
- |
? |
| 1.5.1.33 | 6-biopterin + NADPH + H+ |
- |
Leishmania sp. |
5,6,7,8-tetrahydrobiopterin + NADP+ |
- |
? |
| 1.5.1.33 | 6-biopterin + NADPH + H+ |
- |
Leishmania sp. BK-2007 |
5,6,7,8-tetrahydrobiopterin + NADP+ |
- |
? |
| 1.5.1.33 | 7,8-dihydrobiopterin + NADPH + H+ |
- |
Leishmania major |
5,6,7,8-tetrahydrobiopterin + NADP+ |
- |
? |
| 1.5.1.33 | 7,8-dihydrobiopterin + NADPH + H+ |
- |
Leishmania infantum |
5,6,7,8-tetrahydrobiopterin + NADP+ |
- |
? |
| 1.5.1.33 | 7,8-dihydrobiopterin + NADPH + H+ |
- |
Trypanosoma brucei brucei |
5,6,7,8-tetrahydrobiopterin + NADP+ |
- |
? |
| 1.5.1.33 | 7,8-dihydrobiopterin + NADPH + H+ |
- |
Agrobacterium fabrum |
5,6,7,8-tetrahydrobiopterin + NADP+ |
- |
? |
| 1.5.1.33 | 7,8-dihydrobiopterin + NADPH + H+ |
best substrate |
Leishmania major |
5,6,7,8-tetrahydrobiopterin + NADP+ |
- |
? |
| 1.5.1.33 | 7,8-dihydrobiopterin + NADPH + H+ |
best substrate |
Leishmania amazonensis |
5,6,7,8-tetrahydrobiopterin + NADP+ |
- |
? |
