EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
    1.14.99.1 | (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoic acid + AH2 + O2 |
- |
Ovis aries |
? + A + H2O |
- |
? |
| 1.14.99.1 | (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoic acid + AH2 + O2 |
- |
Salvelinus fontinalis |
? + A + H2O |
- |
? |
| 1.14.99.1 | (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoic acid + AH2 + O2 |
the substrate is bound in the cyclooxygenase channel of COX-2, binding structure, overview. The carboxylate of docosahexaenoate interacts with Arg120 and Tyr355 at the base of the channel and the omega-end abuts the side chain of Ile377 near Gly533 in the hydrophobic groove above Ser530 |
Mus musculus |
? + A + H2O |
- |
? |
| 1.14.99.1 | (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoic acid + AH2 + O2 |
substrate binding structure and nonproductive conformation, overview |
Mus musculus |
? + A + H2O |
- |
? |
| 1.14.99.1 | 8,11,14-eicosatrienoic acid + O2 |
- |
Bos taurus |
prostaglandin G1 + ? |
- |
? |
| 1.14.99.1 | 8,11,14-eicosatrienoic acid + O2 |
bis-dioxygenase activity, cyclooxygenase activity, presence of hematin |
Bos taurus |
prostaglandin G1 + ? |
9alpha,11alpha-epidioxy-15(S)-hydroperoxy-13-trans-prostenoic acid |
? |
| 1.14.99.1 | 8,11,14-eicosatrienoic acid + O2 |
- |
Bos taurus |
prostaglandin H1 + ? |
- |
? |
| 1.14.99.1 | 8,11,14-eicosatrienoic acid + O2 |
hydroperoxidase activity, presence of hematin and tryptophan |
Bos taurus |
prostaglandin H1 + ? |
- |
? |
| 1.14.99.1 | alpha-linolenic acid + reduced acceptor + O2 |
- |
Ovis aries |
? |
- |
r |
| 1.14.99.1 | alpha-linolenic acid + reduced acceptor + O2 |
- |
Salvelinus fontinalis |
? |
- |
r |
