EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.14.19.8 | more |
no activity with substrate analogue 6,7-dihydropentalenolactone, because the C1 carbocation is not anchimerically stabilized by the 6,7-double bond of pentalenolactone F. Enzyme-ligand interaction via three residues, F232, M77, and M81 that are unique to PntM and its orthologues and absent from essentially all other P450s |
Streptomyces arenae |
? |
- |
? |
1.14.19.8 | pentalenolactone F + O2 + 2 reduced ferredoxin + 2 H+ |
- |
Streptomyces exfoliatus |
pentalenolactone + 2 oxidized ferredoxin + 2 H2O |
- |
ir |
1.14.19.8 | pentalenolactone F + O2 + 2 reduced ferredoxin + 2 H+ |
- |
Streptomyces avermitilis |
pentalenolactone + 2 oxidized ferredoxin + 2 H2O |
- |
ir |
1.14.19.8 | pentalenolactone F + O2 + 2 reduced ferredoxin + 2 H+ |
- |
Streptomyces arenae |
pentalenolactone + 2 oxidized ferredoxin + 2 H2O |
- |
ir |
1.14.19.8 | pentalenolactone F + O2 + 2 reduced ferredoxin + 2 H+ |
apparent ability of PntM to catalyze an exclusive carbocation-based oxidative rearrangement |
Streptomyces arenae |
pentalenolactone + 2 oxidized ferredoxin + 2 H2O |
- |
? |
1.14.19.8 | pentalenolactone F + O2 + 2 reduced ferredoxin + 2 H+ |
- |
Streptomyces exfoliatus UC5319 |
pentalenolactone + 2 oxidized ferredoxin + 2 H2O |
- |
ir |
1.14.19.8 | pentalenolactone F + O2 + 2 reduced ferredoxin + 2 H+ |
- |
Streptomyces arenae TUE469 |
pentalenolactone + 2 oxidized ferredoxin + 2 H2O |
- |
ir |
1.14.19.8 | pentalenolactone F + O2 + NADPH + H+ |
- |
Streptomyces exfoliatus |
pentalenolactone + NADP+ + H2O |
- |
? |
1.14.19.8 | pentalenolactone F + O2 + NADPH + H+ |
- |
Streptomyces arenae |
pentalenolactone + NADP+ + H2O |
- |
? |
1.14.19.8 | pentalenolactone F + O2 + NADPH + H+ |
- |
Streptomyces exfoliatus UC5319 |
pentalenolactone + NADP+ + H2O |
- |
? |