EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.14.18.B1 | histone H3 N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2 |
- |
Danio rerio |
histone H3 N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2 |
- |
? |
1.14.18.B1 | histone H3 N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2 |
- |
Homo sapiens |
histone H3 N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2 |
- |
? |
1.14.18.B1 | histone H3 N6,N6-dimethyl-L-lysine27 + 2-oxoglutarate + O2 |
- |
Homo sapiens |
histone H3 N6-methyl-L-lysine27 + succinate + formaldehyde + CO2 |
- |
? |
1.14.18.B1 | more |
enzyme PHF8 binds and stabilizes histone H3 N6,N6,N6-trimethyl-L-lysine4, PHF8 is important in maintaining H3K4me3 levels. PHF8 cooperates with KDM3A |
Homo sapiens |
? |
- |
? |
1.14.18.B1 | more |
the enzyme also demethylates mono- and dimethylated H3 Lys9 (H3K9Me1/2) and monomethylated histone H4 Lys20 residue (H4K20Me1) |
Homo sapiens |
? |
- |
? |