EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   1.14.18.6 | a phytoceramide + 2 ferrocytochrome b5 + O2 + 2 H+ |
- |
Saccharomyces cerevisiae |
a (2'R)-2'-hydroxyphytoceramide + 2 ferricytochrome b5 + H2O |
- |
? |
| 1.14.18.6 | a phytoceramide + 2 ferrocytochrome b5 + O2 + 2 H+ |
a phytoceramide, containing a 26-carbon very-long-chain fatty acid (VLCFA) moiety, is used as the model substrate |
Saccharomyces cerevisiae |
a (2'R)-2'-hydroxyphytoceramide + 2 ferricytochrome b5 + H2O |
- |
? |
| 1.14.18.6 | monohexosylceramide + 2 ferrocytochrome b5 + O2 + 2 H+ |
- |
Mus musculus |
2'-hydroxymonohexosylceramide + 2 ferricytochrome b5 + H2O |
- |
? |
| 1.14.18.6 | more |
2-hydroxylation of fatty acid by FA2H occurs prior to generation of ceramides/glucosylceramides. FA2H expression and 2-hydroxy-free fatty acid production increase early in keratinocyte differentiation, production of 2-hydroxyceramides/2-hydroxyglucosylceramides with longer chain amide-linked fatty acids (more than C24) increases later |
Homo sapiens |
? |
- |
? |
| 1.14.18.6 | more |
FA2H is stereospecific for the production of (R)-enantiomers |
Mus musculus |
? |
- |
? |
| 1.14.18.6 | more |
initiates fatty acid alpha-oxidation and is also responsible for the biosynthesis of 2-hydroxy fatty acid-containing sphingolipids in mammalian cells |
Homo sapiens |
? |
- |
? |
| 1.14.18.6 | more |
molecular dynamics simulations, allows modeling of a ceramide substrate below the dimetal center of scScs7p |
Saccharomyces cerevisiae |
? |
- |
? |
| 1.14.18.6 | palmitic acid + 2 ferrocytochrome b5 + O2 + 2 H+ |
- |
Homo sapiens |
(R)-2-hydroxypalmitic acid + 2 ferricytochrome b5 + H2O |
FA2H is stereospecific for the production of (R)-enantiomers |
? |
| 1.14.18.6 | phytoceramide + ferrocytochrome b5 + O2 + H+ |
- |
Saccharomyces cerevisiae |
(2'R)-2'-hydroxyphytoceramide + ferricytochrome b5 + H2O |
- |
? |
