EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.14.15.33 | 10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 |
involved in the biosynthesis of a number of bacterial macrolide antibiotics containing a desosamine glycoside unit |
Streptomyces venezuelae |
novamethymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O |
- |
? |
1.14.15.33 | 10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 |
with 10-deoxymethymycin it hydroxylates at either C-10 to give methymycin or C-12 to give neomethymycin or both positions to give novamethymycin |
Streptomyces venezuelae |
novamethymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O |
- |
? |
1.14.15.33 | 10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 |
- |
Saccharopolyspora erythraea |
methymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O |
- |
? |
1.14.15.33 | 10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 |
involved in the biosynthesis of a number of bacterial macrolide antibiotics containing a desosamine glycoside unit |
Streptomyces venezuelae |
methymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O |
- |
? |
1.14.15.33 | 10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 |
with 10-deoxymethymycin it hydroxylates at either C-10 to give methymycin or C-12 to give neomethymycin or both positions to give novamethymycin |
Streptomyces venezuelae |
methymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O |
- |
? |
1.14.15.33 | 10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 |
i.e. YC-17 |
Streptomyces venezuelae |
methymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O |
- |
? |
1.14.15.33 | 10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 |
i.e. YC-17. 40% conversion, ratio of products neomethymycin to methymycin is 0.81 |
Streptomyces venezuelae |
methymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O |
- |
? |
1.14.15.33 | 10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 |
- |
Saccharopolyspora erythraea |
neomethymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O |
- |
? |
1.14.15.33 | 10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 |
- |
Streptomyces venezuelae |
neomethymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O |
- |
? |
1.14.15.33 | 10-deoxymethymycin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 |
involved in the biosynthesis of a number of bacterial macrolide antibiotics containing a desosamine glycoside unit |
Streptomyces venezuelae |
neomethymycin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O |
- |
? |