EC Number   |
Substrates |
Organism |
Products |
Reversibility  |
|---|
    1.14.14.5 | more |
when both the lid and C-terminus are ordered and bound in ternary-MsuD, the active site appears completely enclosed from bulk solvent. The apparent volume is larger than methanesulfonate (MS-), consistent with previously observed activity against larger sulfonate substrates. Therefore, molecular docking of substrates ranging in size from pentanesulfonate to PIPES is explored. Docking returns possible poses with the sulfonate moiety in a similar orientation as observed for MS-, but with variable positioning of alkyl groups. Molecular docking defines MsuD as a small- to medium-chain alkanesulfonate monooxygenase. Substrate binding structures for methanesulfonate (alkanesulfonate), FMNH2, and O2, involving the enzyme's C-terminuns, overview |
Pseudomonas fluorescens |
? |
- |
- |
| 1.14.14.5 | more |
when both the lid and C-terminus are ordered and bound in ternary-MsuD, the active site appears completely enclosed from bulk solvent. The apparent volume is larger than methanesulfonate (MS-), consistent with previously observed activity against larger sulfonate substrates. Therefore, molecular docking of substrates ranging in size from pentanesulfonate to PIPES is explored. Docking returns possible poses with the sulfonate moiety in a similar orientation as observed for MS-, but with variable positioning of alkyl groups. Molecular docking defines MsuD as a small- to medium-chain alkanesulfonate monooxygenase. Substrate binding structures for methanesulfonate (alkanesulfonate), FMNH2, and O2, involving the enzyme's C-terminuns, overview |
Pseudomonas fluorescens Pf0-1 |
? |
- |
- |
| 1.14.14.5 | 1,3-dioxo-2-isoindolineethanesulfonic acid + FMNH2 + O2 |
- |
Escherichia coli |
(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetaldehyd + FMN + sulfite + H2O |
- |
? |
| 1.14.14.5 | 2-(4-pyridyl)ethanesulfonic acid + FMNH2 + O2 |
- |
Escherichia coli |
pyridin-4-ylacetaldehyde |
- |
? |
| 1.14.14.5 | 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate + FMNH2 + O2 |
HEPES |
Pseudomonas fluorescens |
? + FMN + sulfite + H2O |
- |
? |
| 1.14.14.5 | 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate + FMNH2 + O2 |
HEPES |
Pseudomonas fluorescens Pf0-1 |
? + FMN + sulfite + H2O |
- |
? |
| 1.14.14.5 | 3-(N-morpholino)propanesulfonate + FMNH2 + O2 |
MOPS |
Pseudomonas fluorescens |
? + FMN + sulfite + H2O |
- |
? |
| 1.14.14.5 | 4-phenyl-1-butanesulfonic acid + FMNH2 + O2 |
- |
Escherichia coli |
4-phenylbutanol + FMN + sulfite + H2O |
- |
? |
| 1.14.14.5 | an alkanesulfonate + FMNH2 + O2 |
- |
Escherichia coli |
an aldehyde + FMN + sulfite + H2O |
- |
? |
| 1.14.14.5 | an alkanesulfonate + FMNH2 + O2 |
- |
Pseudomonas fluorescens |
an aldehyde + FMN + sulfite + H2O |
- |
? |
