EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.14.13.182 | 2-heptyl-1-hydroxyquinolin-4(1H)-one + NADH + H+ + O2 |
- |
Staphylococcus aureus |
2-heptyl-1,3-dihydroxy-4(1H)-quinolone + NAD+ + H2O |
- |
? |
1.14.13.182 | 2-heptyl-1-hydroxyquinolin-4(1H)-one + NADH + H+ + O2 |
- |
Mycobacteroides abscessus |
2-heptyl-1,3-dihydroxy-4(1H)-quinolone + NAD+ + H2O |
- |
? |
1.14.13.182 | 2-heptyl-1-hydroxyquinolin-4(1H)-one + NADH + H+ + O2 |
- |
Mycobacteroides abscessus DSM 44196 |
2-heptyl-1,3-dihydroxy-4(1H)-quinolone + NAD+ + H2O |
- |
? |
1.14.13.182 | 2-heptyl-1-hydroxyquinolin-4(1H)-one + NADH + H+ + O2 |
- |
Staphylococcus aureus Newman |
2-heptyl-1,3-dihydroxy-4(1H)-quinolone + NAD+ + H2O |
- |
? |
1.14.13.182 | 2-heptyl-1-hydroxyquinolin-4(1H)-one one + NADH + H+ + O2 |
- |
Pseudomonas aeruginosa |
2-heptyl-1,3-dihydroxy-4(1H)-quinolone + NAD+ + H2O |
- |
? |
1.14.13.182 | 2-heptyl-1-hydroxyquinolin-4(1H)-one one + NADH + H+ + O2 |
- |
Microbulbifer sp. HZ11 |
2-heptyl-1,3-dihydroxy-4(1H)-quinolone + NAD+ + H2O |
- |
? |
1.14.13.182 | 2-heptyl-1-hydroxyquinolin-4(1H)-one one + NADH + H+ + O2 |
- |
Pseudomonas aeruginosa DSM 22644 |
2-heptyl-1,3-dihydroxy-4(1H)-quinolone + NAD+ + H2O |
- |
? |
1.14.13.182 | 2-heptyl-4(1H)-quinolone + NADH + H+ + O2 |
PqsH catalyzes the terminal step in biosynthesis of the Pseudomonas quinolone signal molecule 2-heptyl-3-hydroxy-4(1H)-quinolone. Under anaerobic conditions 2-heptyl-3-hydroxy-4(1H)-quinolone is not produced. The enzyme is a biochemical regulator of Pseudomonas quinolone signal controlled social behaviors in Pseudomonas aeruginosa |
Pseudomonas aeruginosa |
2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O |
- |
? |
1.14.13.182 | 2-heptyl-4(1H)-quinolone + NADH + H+ + O2 |
the alkyl side chain of 2-heptyl-4-quinolone is critical for PqsH activity with the highest activity observed for alkyl chain lengths of 7 and 9 carbons |
Pseudomonas aeruginosa |
2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O |
- |
? |
1.14.13.182 | 2-heptyl-4(1H)-quinolone + NADPH + H+ + O2 |
kcat/KM for NADH is 20fold higher than kcat/Km for NADPH |
Pseudomonas aeruginosa |
2-heptyl-3-hydroxy-4(1H)-quinolone + NADP+ + H2O |
- |
? |