EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   1.14.11.54 | 5'-dAAAA-1-methyl-AYYAAA + 2-oxoglutarate + O2 |
- |
Homo sapiens |
5'-dAAAAAYYAAA + formaldehyde + succinate + CO2 |
- |
? |
| 1.14.11.54 | more |
ALKBH3 demethylates 3-meC, 1-meA, and N6-meA in the presence of 2-oxoglutarate and Fe(II). ALKBH3 preferentially demethylates N6-meA in tRNA |
Bombyx mori |
? |
- |
- |
| 1.14.11.54 | N1-methyladenine in mRNA + 2-oxoglutarate + O2 |
- |
Bombyx mori |
adenine in mRNA + formaldehyde + succinate + CO2 |
- |
? |
| 1.14.11.54 | N1-methyladenine in mRNA + 2-oxoglutarate + O2 |
- |
Homo sapiens |
adenine in mRNA + formaldehyde + succinate + CO2 |
- |
? |
| 1.14.11.54 | N1-methyladenine in mRNA + 2-oxoglutarate + O2 |
N1-methyladenine is prevalent in Homo sapiens mRNA, which shows an N1-methyladenine/adenine ratio of about 0.02%. Methylation of adenine in mRNA is reversible by ALKBH3. Recombinant ALKBH3 protein has robust demethylation activity against a synthetic RNA substrate containing a sitespecifically incorporated m1A modification |
Homo sapiens |
adenine in mRNA + formaldehyde + succinate + CO2 |
- |
? |
| 1.14.11.54 | N1-methyladenine in ssDNA + 2-oxoglutarate + O2 |
- |
Homo sapiens |
adenine in ssDNA + formaldehyde + succinate + CO2 |
- |
? |
| 1.14.11.54 | N1-methyladenine in tRNA + 2-oxoglutarate + O2 |
- |
Homo sapiens |
adenine in tRNA + formaldehyde + succinate + CO2 |
- |
? |
| 1.14.11.54 | N3-ethylthymidine in mRNA + 2-oxoglutarate + O2 |
- |
Mus musculus |
thymidine in mRNA + ? |
- |
? |
| 1.14.11.54 | N3-methylcytidine in mRNA + 2-oxoglutarate + O2 |
- |
Bombyx mori |
cytidine in mRNA + formaldehyde + succinate + CO2 |
- |
? |
| 1.14.11.54 | N3-methylcytidine in tRNA + 2-oxoglutarate + O2 |
- |
Homo sapiens |
cytidine in tRNA + formaldehyde + succinate + CO2 |
- |
? |
