EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.1.1.248 | more |
alkaloid composition of the organism |
Papaver somniferum |
? |
- |
? |
1.1.1.248 | more |
no reduction of 1,2-nordehydroreticuline, 1,2-dehydroreticulinium ion, codeinone, tropinone, or (-)-menthone, no oxidation of (R)-norreticuline, (R)-reticuline, codeine, tropine, or (+)-neomenthol |
Papaver somniferum |
? |
- |
? |
1.1.1.248 | more |
the enzyme is involved in the biosynthesis of morphine |
Papaver bracteatum |
? |
- |
? |
1.1.1.248 | more |
interaction of benzylisoquinoline alkaloids with enzymes, modeling, overview |
Papaver bracteatum |
? |
- |
? |
1.1.1.248 | more |
occurrence of active SalR homologue in Papaver pilosum, although it does not produce salutaridine or any other promorphinan alkaloid |
Papaver pilosum |
? |
- |
? |
1.1.1.248 | more |
occurrence of active SalR homologue in Papaver pyrenaicum, although it does not produce salutaridine or any other promorphinan alkaloid |
Papaver pyrenaicum |
? |
- |
? |
1.1.1.248 | more |
alkaloid composition of the organism |
Papaver somniferum salR |
? |
- |
? |
1.1.1.248 | more |
no reduction of 1,2-nordehydroreticuline, 1,2-dehydroreticulinium ion, codeinone, tropinone, or (-)-menthone, no oxidation of (R)-norreticuline, (R)-reticuline, codeine, tropine, or (+)-neomenthol |
Papaver somniferum salR |
? |
- |
? |
1.1.1.248 | salutaridine + NAD(P)H + H+ |
NADPH is the highly preferred cofactor, the enzyme shows high substrate specificity, no activity with tropinone, (2)-menthone, codeinone and dehydroreticulinium ion, or nordehydroreticuline. Asp152, Ser180, Tyr236, and Lys240 are involved in the proton transfer system for the reduction of salutaridine, substrate-active site binding structure, overview |
Papaver bracteatum |
(7S)-salutaridinol + NAD(P)+ |
the enzyme produces only the (7S)-salutaridinol stereoisomer as product, not the stereoisomer 7-epi-salutaridinol |
r |
1.1.1.248 | salutaridine + NADH + H+ |
- |
Papaver bracteatum |
salutaridinol + NAD+ |
- |
r |