EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.1.1.147 | 16-ketotestosterone + NAD(P)H |
- |
Rattus sp. |
16alpha-hydroxytestosterone + NAD(P)+ |
- |
r |
1.1.1.147 | 16-oxo-17beta-estradiol + NADH + H+ |
- |
Rattus sp. |
16alpha-hydroxy-17beta-estradiol + NAD+ |
- |
r |
1.1.1.147 | 17alpha-estradiol-16-one + NAD(P)H |
best substrate tested, changing configuration or oxidation state of the neighboring oxygen substituent at C-17 increases the rate of reduction |
Rattus sp. |
16alpha-hydroxy-17alpha-estradiol + NAD(P)+ |
- |
r |
1.1.1.147 | 17beta-estradiol-16-one + NAD(P)H |
- |
Homo sapiens |
16alpha-hydroxy-17beta-estradiol + NAD(P)+ |
- |
r |
1.1.1.147 | 17beta-estradiol-16-one + NAD(P)H |
- |
Rattus sp. |
16alpha-hydroxy-17beta-estradiol + NAD(P)+ |
- |
r |
1.1.1.147 | 3-hydroxy-estra-1,3,5(10)-triene-16,17-dione + NAD(P)H + H+ |
- |
Rattus sp. |
3,16alpha-dihydroxy-estra-1,3,5(10)-triene-17-one + NAD(P)+ |
- |
r |
1.1.1.147 | 3beta,17beta-dihydroxy-androst-5-en-16-one + NAD(P)H |
low activity |
Rattus sp. |
3beta,16alpha,17beta-trihydroxyandrost-5-ene + NAD(P)+ |
- |
? |
1.1.1.147 | estra-1,3,5(10)-triene-3,16beta,17beta-triol + NAD(P)+ |
- |
Rattus sp. |
estra-1,3,5(10)-triene-3,17beta-diol-16-one + NAD(P)H |
- |
? |
1.1.1.147 | estra-1,3,5(10)triene-3,17-beta-diol-16-one + NAD(P)H |
low activity |
Rattus sp. |
estra-1,3,5(10)triene-3,16alpha,17-triol + NAD(P)+ |
- |
r |