EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
3.6.1.12 | dCDP + H2O |
- |
Escherichia phage T2 |
? |
- |
? |
3.6.1.12 | dCTP + H2O |
- |
Escherichia phage T2 |
dCMP + diphosphate |
- |
? |
3.6.1.12 | dCTP + H2O |
the enzyme is essential for normal development of all T-even phages. It prevents the incorporation of dC into phage DNA by hydrolyzing dCTP and dCDP. No role of the T4 dCTPase protein in either the host-dependent or the host-independent exclusion of phage T2 by T4 |
Escherichia phage T2 |
dCMP + diphosphate |
- |
? |
3.6.1.12 | 5-bromo-dCTP + H2O |
- |
Homo sapiens |
5-bromo-dCMP + diphosphate |
- |
? |
3.6.1.12 | 5-formyl-dCTP + H2O |
- |
Homo sapiens |
5-formyl-dCMP + diphosphate |
- |
? |
3.6.1.12 | 5-hydroxymethyl-dCTP + H2O |
- |
Homo sapiens |
5-hydroxymethyl-dCMP + diphosphate |
- |
? |
3.6.1.12 | 5-iodo-dCTP + H2O |
- |
Homo sapiens |
5-iodo-dCMP + diphosphate |
- |
? |
3.6.1.12 | 5-iodo-dCTP + H2O |
good substrate |
Homo sapiens |
5-iodo-dCMP + diphosphate |
- |
? |
3.6.1.12 | 5-methyl-dCTP + H2O |
- |
Homo sapiens |
5-methyl-dCMP + diphosphate |
- |
? |
3.6.1.12 | aza-dCTP + H2O |
the enzyme can hydrolyse the activated form of decitabine, aza-dCTP, and might constitute a novel route in the detoxification of this DNA-methylation inhibitor |
Homo sapiens |
dCMP + diphosphate |
- |
? |