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Results 1 - 10 of 62 > >>
EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
aggrecan + H2O
cleavage site is Asn341-Phe342
?
-
?
ameloblastin + H2O
MMP-20 cleaves ameloblastin after Pro2, Gln130, Gln139, Arg170, and Ala222
ameloblastin fragments
fragments of 23 kDa, 17 kDa, and 15 kDa
?
ameloblastin + H2O
N-terminal ameloblastin cleavage products of 13, 15, and 17 kDa accumulate in the sheath space throughout the enamel layer
ameloblastin fragments
-
?
ameloblastin + H2O
MMP-20 cleaves the recombinant porcine substrate at multiple sites on the N-terminal side of the protein to fragments that show smaller bands of 7-25 kDa and larger products of 45-65 kDa. MMP-20 starts the cleavage on the N-terminal side of the protein, so that the N-terminal cleavage products are smaller than the C-terminal cleavage products digested by MMP-20 initially at one of three sites—after Gln130. The substrate is digested by MMP-20 initially at one of three sites, after Gln130, Arg170, and Ala222, generating 6 cleavage products. These initial products are then cleaved a second or third time at these same sites, as well as at secondary sites that are located mostly near the C-terminus, after Gly300, Arg319, Ala342, and Asn31 Arg170, and Ala222, generating 6 cleavage products. These initial products are then cleaved a second or third time at these same sites, as well as at secondary sites that are located mostly near the C-terminus, after Gly300, Arg319, Ala342, and Asn31
ameloblastin fragments
mass spectrometry product analysis, overview
?
ameloblastin + H2O
MMP-20 processes ameloblastin during the secretory stage of amelogenesis, cleaves glycosylated recombinant porcine ameloblastin after Pro2, Gln130, Gln139, Arg170, and Ala222. MMP-20 generates the 23-kDa ameloblastin starting at Tyr223, as well as the 17-kDa (Val1-Arg170) and 15-kDa (Val1-Gln130) ameloblastin cleavage products that concentrate in the sheath space during the secretory stage
?
-
?
ameloblastin + H2O
cleaves glycosylated recombinant porcine ameloblastin after Pro2, Gln130, Gln139, Arg170, and Ala222. MMP-20 generates the 23-kDa ameloblastin starting at Tyr223, as well as the 17-kDa (Val1-Arg170) and 15-kDa (Val1-Gln130) ameloblastin cleavage products that concentrate in the sheath space during the secretory stage
?
-
?
amelogenin + H2O
-
amelogenin fragments
-
?
amelogenin + H2O
Mmp-20 cleaves amelogenin sequences after Pro162, Ser148, His62, Ala63, and Trp45. These cleavages generate all of the major cleavage products from tyrosine-rich amelogenin polypeptide that accumulate in porcine secretory stage enamel, i.e. the 23 kDa, 20 kDa, 13 kDa, 11 kDa, and 6 kDa amelogenins. And Mmp-20 cleaves leucine rich-amelogenin protein after Pro45 and Pro40, producing the two LRAP products, Mmp-20 cleavage site preferences, overview
amelogenin fragments
-
?
amelogenin + H2O
cleaves amelogenin between Trp45 and Leu46
23 kDa amelogenin + 5 kDa tyrosine-rich amelogenin peptide
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?
amelogenin + H2O
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?
-
?
Results 1 - 10 of 62 > >>