EC Number   |
Substrates |
Organism  |
Products |
Reversibility |
|---|
   3.4.23.48 | D-Val-Leu-Lys-p-nitroanilide + H2O |
Lpa gene encoding a homologue of the plasminogen activator Pla of Yersinia pestis identified, described as a surface protease exhibiting plasminogen activator activity, plasminogen activity of inner and outer membranes measured |
Legionella pneumophila |
D-Val-Leu-Lys + p-nitroaniline |
- |
? |
| 3.4.23.48 | plasminogen + H2O |
capacity to convert plasminogen into plasmin by the action of the outer-membrane Lpa protein determined |
Legionella pneumophila |
plasmin + ? |
- |
? |
| 3.4.23.48 | D-Val-Leu-Lys-p-nitroanilide + H2O |
Lpa gene encoding a homologue of the plasminogen activator Pla of Yersinia pestis identified, described as a surface protease exhibiting plasminogen activator activity, plasminogen activity of inner and outer membranes measured |
Legionella pneumophila Philadelphia |
D-Val-Leu-Lys + p-nitroaniline |
- |
? |
| 3.4.23.48 | plasminogen + H2O |
capacity to convert plasminogen into plasmin by the action of the outer-membrane Lpa protein determined |
Legionella pneumophila Philadelphia |
plasmin + ? |
- |
? |
| 3.4.23.48 | plasminogen + H2O |
activates plasminogen by cleaving the Arg560-Val561 bond |
Mammalia |
plasmin + ? |
- |
? |
| 3.4.23.48 | alpha2-antiplasmin + H2O |
inactivation |
Yersinia pestis |
? |
- |
? |
| 3.4.23.48 | alpha2-antiplasmin + H2O |
Pla inactivates the main physiologic inhibitor of plasmin |
Yersinia pestis |
? |
- |
? |
| 3.4.23.48 | alpha2-antiplasmin + H2O |
Pla inactivates alpha2-antiplasmin |
Yersinia pestis |
? |
- |
? |
| 3.4.23.48 | alpha2-antiplasmin + H2O |
a serpin |
Yersinia pestis |
? |
- |
? |
| 3.4.23.48 | alpha2-antiplasmin + H2O |
alpha2AP is the main inhibitor of free plasmin in the circulation. Pla cleaves and inactivates alpha2AP by a single, rapid cut. It appears likely that the R376-M377 bait peptide bond is targeted by Pla |
Yersinia pestis |
? |
- |
? |
