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Results 1 - 10 of 33 > >>
EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
alpha2-antiplasmin + H2O
Pla inactivates alpha2-antiplasmin
?
-
?
alpha2-antiplasmin + H2O
a serpin
?
-
?
C3 protein of complement system + H2O
-
fragments of C3 protein of complement system
-
-
C3 protein of complement system + H2O
-
fragments of C3 protein of complement system
-
?
complement protein C3 + H2O
-
?
-
?
D-Val-Leu-Lys-p-nitroanilide + H2O
Lpa gene encoding a homologue of the plasminogen activator Pla of Yersinia pestis identified, described as a surface protease exhibiting plasminogen activator activity, plasminogen activity of inner and outer membranes measured
D-Val-Leu-Lys + p-nitroaniline
-
?
D-Val-Leu-Lys-p-nitroanilide + H2O
Lpa gene encoding a homologue of the plasminogen activator Pla of Yersinia pestis identified, described as a surface protease exhibiting plasminogen activator activity, plasminogen activity of inner and outer membranes measured
D-Val-Leu-Lys + p-nitroaniline
-
?
human alpha2-antiplasmin + H2O
-
fragments of alpha2-antiplasmin
-
-
more
plasminogen activator Pla is essential for the spread of Yersinia pestis from the subcutaneous infection site into circulation, and the proteolytic activation of plasminogen is involved in virulence function. In addition to proteolysis plasminogen activator Pla promotes bacterial adhesion to mammalian extracellular matrices and epithelial cells as well as bacterial invasion into eukayotic cells. Laminin functions as an adhesion target for plasminogen activator Pla, which also expresses a lower adhesion affinity for heparan sulfate proteoglycan. the adhesion targets are not directly degraded by plasminogen activator Pla, but Pla-mediated generation of plasmin leads to their degradation
?
-
-
more
plasminogen activator plays a pivotal role in internalisation of bacteria by HeLa cells. Intracellular signalling and cytoskeletal rearrangement is involved in Yersinia pestis plasminogen activator mediated HeLa cell invasion
?
-
-
Results 1 - 10 of 33 > >>