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EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
3.4.22.69
(CAL fluor red 610)-TSAVLQSGFRK(BHQ1) + H2O
-
Severe acute respiratory syndrome-related coronavirus
(CAL fluor red 610)-TSAVLQ + SGFRK(BHQ1)
-
?
3.4.22.69
2-aminobenzoyl-TSAVLQSGFRK-2,4-dinitrophenyl amide + H2O
-
Severe acute respiratory syndrome-related coronavirus
2-aminobenzoyl-TSAVLQ + SGFRK-2,4-dinitrophenyl amide
-
?
3.4.22.69
2-aminobenzoyl-SVTLQSG-Tyr(NO2)Arg + H2O
-
Severe acute respiratory syndrome-related coronavirus
?
-
?
3.4.22.69
coronavirus polyprotein + H2O
3CLpro processes the translated polyproteins to functional viral proteins
Severe acute respiratory syndrome-related coronavirus
?
-
?
3.4.22.69
coronavirus polyprotein + H2O
during the formation of the coronaviral replication/transcription complex, essential steps include processing of the conserved polyprotein nsp7-10 region by the main protease Mpro and subsequent complex formation of the released nsps
Severe acute respiratory syndrome-related coronavirus
?
-
?
3.4.22.69
coronavirus polyprotein + H2O
during the formation of the coronaviral replication/transcription complex, essential steps include processing of the conserved polyprotein nsp7-10 region by the main protease Mpro and subsequent complex formation of the released nsps. There is a clear order of cleavage efficiencies, which is influenced by the polyprotein tertiary structure. The predominant product is an nsp7+8(2:2) hetero-tetramer with nsp8 scaffold
Severe acute respiratory syndrome-related coronavirus
?
-
?
3.4.22.69
dabcyl-KTSAVLQSGFRKME-EDANS + H2O
-
Severe acute respiratory syndrome-related coronavirus
?
-
?
3.4.22.69
GPFVDRQTAQAAGTDT-NH2 + H2O
1% of the activity with TSAVLQSGFRK-NH2
Severe acute respiratory syndrome-related coronavirus
?
-
?
3.4.22.69
H-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys-NH2 + H2O
-
Severe acute respiratory syndrome-related coronavirus
?
-
?
3.4.22.69
KVATVQSKMSD-NH2
undecapeptide containing the non-canonical P3/P4 cleavage site of 3CL protease, 6% of the activity with TSAVLQSGFRK-NH2
Severe acute respiratory syndrome-related coronavirus
?
-
?
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