EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.21.B30 | UmuD + H2O |
auto-cleavage of UmuD to UmuD' |
Escherichia coli |
UmuD' + ? |
- |
? |
| 3.4.21.B30 | UmuD2 + H2O |
autocleavage removes the N-terminal 24 amino acids of each UmuD2 to the remaining fragment UmuD2' |
Escherichia coli |
UmuD2' + ? |
- |
? |
| 3.4.21.B30 | more |
binds to a cleft located between two RecA monomers in the crystal structure |
Escherichia coli |
? |
- |
? |
| 3.4.21.B30 | more |
enzyme interacts with RecA |
Escherichia coli |
? |
- |
? |
| 3.4.21.B30 | more |
enzyme UmuD does not bind DNA |
Escherichia coli |
? |
- |
? |
| 3.4.21.B30 | more |
enzyme UmuD does not bind DNA. the enzyme UmuD interacts with several components of DNA polymerase III, including the polymerase subunit alpha, the beta clamp and the proofreading subunit epsilon, homology modeling and protein-protein docking analysis, overview. It interacts with the alpha subunit of DNA polymerase III at two distinct binding sites, one of which is adjacent to the single-stranded DNA-binding site. Enzyme UmuD specifically inhibits binding of DNA polymerase III alpha to ssDNA, UmuD residues D91 and G92 are involved in this interaction, molecular modeling, overview |
Escherichia coli |
? |
- |
? |
| 3.4.21.B30 | more |
interacts with RecA protein |
Escherichia coli |
? |
- |
? |
| 3.4.21.B30 | more |
interacts with RecA-DNA filament and participates in mutagenesis |
Escherichia coli |
? |
- |
? |
| 3.4.21.B30 | more |
role in mutagenesis |
Escherichia coli |
? |
- |
? |
| 3.4.21.B30 | more |
role in SOS mutagenesis |
Escherichia coli |
? |
- |
? |
