EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.7.4.25 | more |
ATP-mediated induced-fit of LID in CMPKcoli modulated by CMP leading to a closed conformation of the active site, protected from water |
Escherichia coli |
? |
- |
? |
2.7.4.25 | more |
bacterial CMP kinases are specific for CMP and dCMP, whereas the related eukaryotic NMP kinase phosphorylates CMP and UMP with similar efficiency. Bacterial CMP kinase has a narrower NMP-binding pocket and a hydrogen-bonding network involving the pyrimidine moiety specific for the cytosine nucleobase compared to eukaryotic UMP?CMP kinases |
Escherichia coli |
? |
- |
? |
2.7.4.25 | more |
four key amino acids interacting with the pyrimidine ring of CMP, Ser36, Asp132, Arg110 and Arg188, contribute to the stability, catalysis and substrate specificity of Escherichia coli CMP kinase. D132 is involved in a complicated network of interactions, the strongest being with R110, and also R110 is involved in many interactions, but mainly with D132. Substrate specificities of wild-type and mutant enzymes, overview |
Escherichia coli |
? |
- |
? |
2.7.4.25 | more |
modelling of CMPK in apo form and in complex with cytidine 5'-monophosphate, structure analysis, overview |
Mycobacterium tuberculosis |
? |
- |
? |
2.7.4.25 | more |
CMP kinase from Salmonella typhimurium does not act on UMP |
Salmonella enterica subsp. enterica serovar Typhimurium |
? |
- |
? |
2.7.4.25 | more |
TMP, Ant-dCMP, 5-methyl-CMP, AMP, dAMP, GMP, and dGMP are no substrates |
Escherichia coli K-12 |
? |
- |
? |
2.7.4.25 | more |
modelling of CMPK in apo form and in complex with cytidine 5'-monophosphate, structure analysis, overview |
Mycobacterium tuberculosis H37Rv |
? |
- |
? |
2.7.4.25 | ATP + 1-beta-D-arabinofuranosylcytosine 5'-phosphate |
- |
Escherichia coli K-12 |
ADP + 1-beta-D-arabinofuranosylcytosine 5'-diphosphate |
- |
? |
2.7.4.25 | ATP + 2-thiouridine 5'-monophosphate |
2-thiouridine 5'-monophosphate is a poor substrate |
Escherichia coli K-12 |
ADP + 2-thiouridine 5'-diphosphate |
- |
? |
2.7.4.25 | ATP + 2',3'-dideoxy-CMP |
2,3-dideoxy-CMP is a poor substrate |
Escherichia coli |
ADP + ? |
- |
? |