EC Number   |
Substrates |
Organism  |
Products |
Reversibility |
|---|
  2.4.99.20 | 2'-phospho-cyclic ADP-ribose + nicotinate |
- |
Aplysia californica |
nicotinate-adenine dinucleotide phosphate |
- |
? |
| 2.4.99.20 | 2'-phospho-cyclic ADP-ribose + nicotinate |
- |
Aplysia californica |
nicotinate-adenine dinucleotide phosphate |
enzyme shows a higher NAADP+-producing activity at pH 5.0 than at pH 7.4. At pH 5.0 the formation of NAADP+ is even more predominant than cADPRP hydrolysis, reaction of EC 3.2.2.6 |
? |
| 2.4.99.20 | more |
enzyme is more efficient in catalyzing the removal of the nicotinamide moiety than in the base-exchange reaction |
Aplysia californica |
? |
- |
? |
| 2.4.99.20 | more |
enzymes cyclizes NAD to cADPR. In the presence of nicotinic acid, it catalyzes a base exchange reaction resulting in the synthesis of nicotinate-adenine dinucleotide phosphate from NADP+. The switch between these two modes of catalysis is regulated by pH |
Aplysia californica |
? |
- |
? |
| 2.4.99.20 | more |
in the absence of nicotinic acid or at neutral pH, isoform CD38 converts NADP+ to ADP-ribose 2'-phosphate, which is the hydrolysis product of cyclic ADPribose 2'-phosphate, reaction of EC 3.2.2.6 |
Aplysia californica |
? |
- |
? |
| 2.4.99.20 | NADP+ |
- |
Aplysia californica |
2'-phospho-cyclic ADP-ribose + nicotinamide |
- |
? |
| 2.4.99.20 | NGDP+ |
enzyme cyclizes nicotinamide guanine dinucleotide to produce a fluorescent product, cyclic GDP-ribose, which has a site of cyclization different from cADPR |
Aplysia californica |
2'-phospho-cyclic GDP-ribose + nicotinamide |
- |
? |
| 2.4.99.20 | 2'-phospho-cyclic ADP-ribose + nicotinate |
- |
Axinella polypoides |
nicotinate-adenine dinucleotide phosphate |
enzyme shows a higher NAADP+-producing activity at pH 5.0 than at pH 7.4. At pH 5.0 the formation of NAADP+ is even more predominant than cADPRP hydrolysis, reaction of EC 3.2.2.6 |
? |
| 2.4.99.20 | more |
enzyme is more efficient in catalyzing the removal of the nicotinamide moiety than in the base-exchange reaction |
Axinella polypoides |
? |
- |
? |
| 2.4.99.20 | NADP+ |
- |
Axinella polypoides |
2'-phospho-cyclic ADP-ribose + nicotinamide |
- |
? |
