EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.1.1.59 | S-adenosyl-L-methionine + CNBr peptide |
- |
Neurospora crassa |
? |
- |
? |
2.1.1.59 | S-adenosyl-L-methionine + cytochrome c L-lysine |
- |
Neurospora crassa |
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine |
- |
? |
2.1.1.59 | S-adenosyl-L-methionine + cytochrome c L-lysine |
horse heart cytochrome c-72 |
Neurospora crassa |
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine |
- |
? |
2.1.1.59 | S-adenosyl-L-methionine + cytochrome c L-lysine |
horse heart cytochrome c-72 |
Neurospora crassa |
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine |
a single lysine residue at position 72 of horse heart cytochrome c is methylated |
? |
2.1.1.59 | S-adenosyl-L-methionine + cytochrome c L-lysine |
horse heart cytochrome c-72 |
Neurospora crassa |
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine |
mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4 |
? |
2.1.1.59 | S-adenosyl-L-methionine + cytochrome c L-lysine |
important features in determining methyl-accepting activity: 1. reactive site such as-X-Lys-Lys-Y-, 2. length of polypeptide chain, 3. tertiary structure |
Neurospora crassa |
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine |
a single lysine residue at position 72 of horse heart cytochrome c is methylated |
? |
2.1.1.59 | S-adenosyl-L-methionine + cytochrome c L-lysine |
important features in determining methyl-accepting activity: 1. reactive site such as-X-Lys-Lys-Y-, 2. length of polypeptide chain, 3. tertiary structure |
Neurospora crassa |
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine |
mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4 |
? |
2.1.1.59 | S-adenosyl-L-methionine + cytochrome c L-lysine |
does not randomly methylate cytochrome c, but shows absolute specificity for some amino acid sequences |
Neurospora crassa |
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine |
a single lysine residue at position 72 of horse heart cytochrome c is methylated |
? |
2.1.1.59 | S-adenosyl-L-methionine + cytochrome c L-lysine |
does not randomly methylate cytochrome c, but shows absolute specificity for some amino acid sequences |
Neurospora crassa |
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine |
mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4 |
? |
2.1.1.59 | S-adenosyl-L-methionine + cytochrome c L-lysine |
also CNBr peptides of horse heart cytochrome c can serve as substrates, overview |
Neurospora crassa |
S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine |
a single lysine residue at position 72 of horse heart cytochrome c is methylated |
? |