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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the reaction diagram Show all sequences 2.1.1.282more bifunctional Trm5a from Pyrococcus abyssi (PaTrm5a) catalyses not only the methylation of N1, but also the further methylation of C7 on 4 demethylwyosine at position 37 to produce isowyosine (EC 2.1.1.228 and EC 2.1.1.282, respectively) Pyrococcus abyssi ? - -
Display the reaction diagram Show all sequences 2.1.1.282more Nanoarchaeum equitans NEQ228 protein displays a dual tRNAPhe:m1G/imG2 methyltransferase activity. Two different types of substrates are used: (1) bulk tRNA, isolated from Salmonella enterica trmDELTA27 mutant containing the unmodified G37 nucleotide leading to the formation of pm1G, and (2) tRNA, which is isolated from the Saccharomes cerevisiae DELTAtyw2 mutant that contains the imG-14 wyosine derivative leading to formation of pimG2pA dinucleotide and to a lesser extent to pm1G, likely resulting from the small amounts of G37-containing tRNAPhe present in the bulk tRNA isolates from the Scetyw2 mutant Nanoarchaeum equitans ? - -
Display the reaction diagram Show all sequences 2.1.1.282more Pyrococcus abyssi PAB2272 protein displays a dual tRNAPhe:m1G/imG2 methyltransferase activity. Two different types of substrates are used: (1) bulk tRNA, isolated from Salmonella enterica trmDELTA27 mutant containing the unmodified G37 nucleotide leading to the formation of pm1G, and (2) tRNA, which is isolated from the Saccharomes cerevisiae DELTAtyw2 mutant that contains the imG-14 wyosine derivative leading to formation of pimG2pA dinucleotide and to a lesser extent to pm1G, likely resulting from the small amounts of G37-containing tRNAPhe present in the bulk tRNA isolates from the Scetyw2 mutant Pyrococcus abyssi ? - -
Display the reaction diagram Show all sequences 2.1.1.282more structural basis for substrate recognition, the D1 domain of the enzyme undergoes large conformational changes upon the binding of tRNA., the enzyme recognizes the overall shape of tRNA. PaTrm5a adopts distinct open conformations before and after the binding of tRNA. Enzyme-substrate interactions in the catalytic domain. The anticodon interactions mostly concentrate on the A36-G37-A38 triplet. Proposed reaction mechanism of Trm5a with modified yeast tRNAPhe, overview Pyrococcus abyssi ? - -
Display the reaction diagram Show all sequences 2.1.1.282more substrate-binding modes of PaTrm5a, and recognition of substrate analogues, overview Pyrococcus abyssi ? - -
Display the reaction diagram Show all sequences 2.1.1.282more Sulfolobus solfataricus SSO2439 protein exhibits a tRNAPhe:imG2, but not tRNAPhe:m1G (EC 2.1.1.228), methyltransferase activity. The enzyme SSO2439 shows incorporation of the [methyl-14C] group into bulk yeast tRNA isolated from Saccharomyces cerevisiae DELTAtyw2 (containing imG-14 in tRNAPhe), but not into that from the Salmonella enterica trmDELTA27 (containing G37) mutant Saccharolobus solfataricus ? - -
Display the reaction diagram Show all sequences 2.1.1.282more Sulfolobus solfataricus SSO2439 protein exhibits a tRNAPhe:imG2, but not tRNAPhe:m1G (EC 2.1.1.228), methyltransferase activity. The enzyme SSO2439 shows incorporation of the [methyl-14C] group into bulk yeast tRNA isolated from Saccharomyces cerevisiae DELTAtyw2 (containing imG-14 in tRNAPhe), but not into that from the Salmonella enterica trmDELTA27 (containing G37) mutant Saccharolobus solfataricus P2 ? - -
Display the reaction diagram Show all sequences 2.1.1.282more Sulfolobus solfataricus SSO2439 protein exhibits a tRNAPhe:imG2, but not tRNAPhe:m1G (EC 2.1.1.228), methyltransferase activity. The enzyme SSO2439 shows incorporation of the [methyl-14C] group into bulk yeast tRNA isolated from Saccharomyces cerevisiae DELTAtyw2 (containing imG-14 in tRNAPhe), but not into that from the Salmonella enterica trmDELTA27 (containing G37) mutant Saccharolobus solfataricus JCM 11322 ? - -
Display the reaction diagram Show all sequences 2.1.1.282more Sulfolobus solfataricus SSO2439 protein exhibits a tRNAPhe:imG2, but not tRNAPhe:m1G (EC 2.1.1.228), methyltransferase activity. The enzyme SSO2439 shows incorporation of the [methyl-14C] group into bulk yeast tRNA isolated from Saccharomyces cerevisiae DELTAtyw2 (containing imG-14 in tRNAPhe), but not into that from the Salmonella enterica trmDELTA27 (containing G37) mutant Saccharolobus solfataricus ATCC 35092 ? - -
Display the reaction diagram Show all sequences 2.1.1.282more Sulfolobus solfataricus SSO2439 protein exhibits a tRNAPhe:imG2, but not tRNAPhe:m1G (EC 2.1.1.228), methyltransferase activity. The enzyme SSO2439 shows incorporation of the [methyl-14C] group into bulk yeast tRNA isolated from Saccharomyces cerevisiae DELTAtyw2 (containing imG-14 in tRNAPhe), but not into that from the Salmonella enterica trmDELTA27 (containing G37) mutant Saccharolobus solfataricus DSM 1617 ? - -
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