EC Number   |
Substrates |
Organism |
Products  |
Reversibility |
|---|
    1.8.4.8 | 5-Phosphoadenosine 3-phosphosulfate + reduced thioredoxin |
enzyme is involved in sulfur metabolism |
Escherichia coli |
? |
- |
? |
| 1.8.4.8 | 5-Phosphoadenosine 3-phosphosulfate + reduced thioredoxin |
essential step in the biosynthesis of Cys in E. coli. Blocking of the enzyme inhibits cell growth |
Escherichia coli |
? |
- |
? |
| 1.8.4.8 | more |
enzyme is essential for sulfate assimilation using phosphoadenosine 5'-phosphosulfate, not adenosine 5'-phosphosulfate, phylogenetic comparison of the 2 different groups, overview |
Escherichia coli |
? |
- |
? |
| 1.8.4.8 | more |
enzyme is involved in sulfate assimilation requiring reduced glutathione and glutaredoxins, redox regulation of the enzyme by glutathione and glutaredoxins, overview |
Escherichia coli |
? |
- |
? |
| 1.8.4.8 | more |
thioredoxin1 and glutaredoxin 1 are essential for sulfate reduction but not for ribonucleotide reduction |
Escherichia coli |
? |
- |
? |
| 1.8.4.8 | more |
cofactor specificity |
Escherichia coli |
? |
- |
? |
| 1.8.4.8 | more |
thioredoxin I mutant W31A shows no detectable activity, whereas W31F, K36E, and D61N are able to serve as electron donors for the APR-catalyzed reaction but with lower turnover numbers than that exhibited by the wild type thioredoxin I. The Km for thioredoxin mutant R73E is increased by 7.7fold compared with wild type thioredoxin I |
Pseudomonas aeruginosa |
? |
- |
? |
| 1.8.4.8 | more |
the redox potential does not determine specificity nor efficiency of the redoxins as reductant. The efficiency of PAPS reductase with various redoxins correlates strongly to the extent of a negative electric field of the redoxins reaching into the solvent outside the active site, and electrostatic and geometric complementary contact surfaces |
Escherichia coli |
? |
- |
? |
| 1.8.4.8 | 3'-phosphoadenylyl-sulfate + glutaredoxin |
- |
Bacillus subtilis |
adenosine 3',5'-bisphosphate + glutaredoxin disulfide + sulfite |
- |
? |
| 1.8.4.8 | 3'-phosphoadenylyl-sulfate + glutaredoxin |
- |
Escherichia coli |
adenosine 3',5'-bisphosphate + glutaredoxin disulfide + sulfite |
- |
? |
